Methazolamide
Methazolamide structure
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Common Name | Methazolamide | ||
|---|---|---|---|---|
| CAS Number | 554-57-4 | Molecular Weight | 236.272 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 402.0±28.0 °C at 760 mmHg | |
| Molecular Formula | C5H8N4O3S2 | Melting Point | 208ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 196.9±24.0 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
Use of MethazolamideMethazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.Target: Carbonic AnhydraseMethazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively [1]. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. Methazolamide does not impair respiratory work performance in anesthetized rabbits [2]. Oral administration of methazolamide decreases IOPs and AHFRs in clinically normal dogs, with effectiveness diminishing in the evening [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Methazolamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.Target: Carbonic AnhydraseMethazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively [1]. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles. Methazolamide does not impair respiratory work performance in anesthetized rabbits [2]. Oral administration of methazolamide decreases IOPs and AHFRs in clinically normal dogs, with effectiveness diminishing in the evening [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 402.0±28.0 °C at 760 mmHg |
| Melting Point | 208ºC (dec.) |
| Molecular Formula | C5H8N4O3S2 |
| Molecular Weight | 236.272 |
| Flash Point | 196.9±24.0 °C |
| Exact Mass | 236.003784 |
| PSA | 144.03000 |
| LogP | 0.13 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.737 |
| InChIKey | FLOSMHQXBMRNHR-UHFFFAOYSA-N |
| SMILES | CC(=O)N=c1sc(S(N)(=O)=O)nn1C |
| Storage condition | 2-8°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 + H312 + H332-H351 |
| Precautionary Statements | P261-P280-P301 + P312 + P330 |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R20/21/22;R40 |
| Safety Phrases | S22-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AC6350000 |
| HS Code | 2935009090 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
|---|---|
| DownStream 0 | |
![5-acetylimino-4-methyl-4,5-dihydro-[1,3,4]thiadiazole-2-sulfonyl chloride Structure](https://image.chemsrc.com/caspic/094/114224-34-9.png)
CAS#:114224-34-9This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Inhibition of hyperactivity and impulsivity by carbonic anhydrase inhibitors in spontaneously hypertensive rats, an animal model of ADHD.
Psychopharmacology 232 , 3763-72, (2015) Dysregulation of noradrenergic and dopaminergic systems is involved in the pathology of attention deficit hyperactivity disorder (ADHD). Carbonic anhydrase (CA) has been reported to affect monoamine t... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| N-[(2E)-5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide |
| methazolamide |
| Methazolamide [BAN:INN:JAN] |
| Methazolamide (JAN/USP) |
| EINECS 209-066-7 |
| N-(4-Methyl-2-sulfamoyl-D2-1,3,4-thiadiazolin-5-ylidene)acetamide |
| Metazolamide [DCIT] |
| 5-Acetylamino-4-methyl-D2-1,3,4-thiadiazoline-2-sulfonamide |
| NEPTAZANE |
| N1-[5-(aminosulfonyl)-3-methyl-2,3-dihydro-1,3,4-thiadiazol-2-yliden]acetamide |
| 4-27-00-08221 (Beilstein Handbook Reference) |
| N-[(2Z)-3-Methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide |
| N-[5-(Aminosulfonyl)-3-methyl-1,3,4-triadiazol-2(3H)-ylidene]acetamide |
| N-[(2E)-3-Methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide |
| MFCD00083416 |
| N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of Methazolamide? |
| A: CAS number of Methazolamide is 554-57-4. |
| Q: What is the boiling point of Methazolamide? |
| A: Boiling point of Methazolamide is 402.0±28.0 °C at 760 mmHg. |
| Q: What is the melting point of Methazolamide? |
| A: Melting point of Methazolamide is 208ºC (dec.). |
| Q: What is the InChIKey of Methazolamide? |
| A: InChIKey of Methazolamide is FLOSMHQXBMRNHR-UHFFFAOYSA-N. |
| Q: What is the molecular formula of Methazolamide? |
| A: Molecular formula of Methazolamide is C5H8N4O3S2. |
| Q: What is the SMILES notation of Methazolamide? |
| A: SMILES notation of Methazolamide is CC(=O)N=c1sc(S(N)(=O)=O)nn1C. |
| Q: What is the LogP of Methazolamide? |
| A: LogP of Methazolamide is 0.13. |
| Q: What is the English name of Methazolamide? |
| A: The English name of Methazolamide is Methazolamide. |
| Q: What are the upstream materials of Methazolamide? |
| A: Related upstream materials(CAS) of Methazolamide: 114224-34-9. |
| Q: What is the safety information for Methazolamide? |
| A: Safety information for Methazolamide: S22-S36. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |