Iprindole

Modify Date: 2024-01-10 14:59:52

Iprindole structure	Common Name	Iprindole
	CAS Number	5560-72-5	Molecular Weight	284.43900
	Density	1.04g/cm3	Boiling Point	435.4ºC at 760mmHg
	Molecular Formula	C₁₉H₂₈N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	217.1ºC

Use of Iprindole

Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].

Name	3-(6,7,8,9,10,11-hexahydrocycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine
Synonym	More Synonyms

Description	Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	Iprindole produces less than 50% inhibition of the uptake of noradrenaline as well as that of 5-HT at 100 mg/kg i .p..
References	[1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.

Density	1.04g/cm3
Boiling Point	435.4ºC at 760mmHg
Molecular Formula	C₁₉H₂₈N₂
Molecular Weight	284.43900
Flash Point	217.1ºC
Exact Mass	284.22500
PSA	8.17000
LogP	4.25200
Index of Refraction	1.573

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY0350000

CHEMICAL NAME :: 5H-Cyclooct(b)indole, 5-(3-(dimethylamino)propyl)-6,7,8,9,10,11-hexahydro-

CAS REGISTRY NUMBER :: 5560-72-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H28-N2

MOLECULAR WEIGHT :: 284.49

WISWESSER LINE NOTATION :: T B658 HN&&TJ H3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 775 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 187 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 484 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,130,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01206

Bromocyclooctane structure

Bromocyclooctane

CAS#:1556-09-8

Benzenediazonium tetrafluoroborate structure

Benzenediazoniu...

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3-Chloro-N,N-dimethylpropan-1-amine structure

3-Chloro-N,N-di...

CAS#:109-54-6

~72%

Iprindole Structure

Iprindole

CAS#:5560-72-5

Literature: Zhang, Zhi-Guang; Haag, Benjamin A.; Li, Jin-Shan; Knochel, Paul Synthesis, 2011 , # 1 p. 23 - 29

3-Chloro-N,N-dimethylpropan-1-amine structure

3-Chloro-N,N-di...

CAS#:109-54-6

5H-Cyclooct[b]indole,6,7,8,9,10,11-hexahydro- structure

5H-Cyclooct[b]i...

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~%

Iprindole Structure

Iprindole

CAS#:5560-72-5

Literature: Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

N/A structure

N/A

CAS#:1401315-71-6

~%

Iprindole Structure

Iprindole

CAS#:5560-72-5

Literature: Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

zhucan-4-141 structure

zhucan-4-141

CAS#:1402424-10-5

~%

Iprindole Structure

Iprindole

CAS#:5560-72-5

Literature: Zhu, Can; Zhang, Xue; Lian, Xiongdong; Ma, Shengming Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7817 - 7820

Precursor 4
CAS#:1556-09-8 Bromocyclooctane CAS#:369-57-3 Benzenediazoniu... CAS#:109-54-6 3-Chloro-N,N-di... CAS#:22793-63-1 5H-Cyclooct[b]i...
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Pramindole

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DC Chemicals Limited
China
Product Name: Iprindole
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5H-Cyclooct[b]indole-5-propanamine,6,7,8,9,10,11-hexahydro-N,N-dimethyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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