伊普吲哚

• 常用名: 伊普吲哚
• 英文名: Iprindole
• CAS号: 5560-72-5
• 分子量: 284.43900
• 密度: 1.04g/cm3
• 沸点: 435.4ºC at 760mmHg
• 分子式: C₁₉H₂₈N₂
• 熔点: N/A
• 闪点: 217.1ºC

伊普吲哚用途

Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。

伊普吲哚名称

• 中文名: 伊普吲哚
• 英文名: 3-(6,7,8,9,10,11-hexahydrocycloocta[b]indol-5-yl)-N,N-dimethylpropan-1-amine

伊普吲哚生物活性

• 描述: Iprindole 具有抗抑郁的生物活性,是一种弱的去甲肾上腺素和5-HT 摄取的抑制剂。
• 相关类别:
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
  信号通路 >> 神经信号通路 >> 5-HT受体
• 体内研究: 依哌利多对去甲肾上腺素和5-羟色胺摄取的抑制作用小于50%,剂量为100 mg/kg。。
• 参考文献:

  [1]. M I Gluckman, et al. The pharmacology of iprindole, a new antidepressant. Psychopharmacologia. 1969;15(3):169-85.

伊普吲哚物理化学性质

• 密度: 1.04g/cm3
• 沸点: 435.4ºC at 760mmHg
• 分子式: C₁₉H₂₈N₂
• 分子量: 284.43900
• 闪点: 217.1ºC
• 精确质量: 284.22500
• PSA: 8.17000
• LogP: 4.25200
• InChIKey: PLIGPBGDXASWPX-UHFFFAOYSA-N
• SMILES: CN(C)CCCn1c2c(c3ccccc31)CCCCCC2
• 外观性状: 油状物
• 折射率: 1.573
• 储存条件: 2-8°C，密封，干燥

伊普吲哚毒性和生态

伊普吲哚靶点实验

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实验名称：Binding affinity towards human DRD5 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(1B) dopamine receptor External Id：CHEMBL5291784

实验名称：Binding affinity towards human DRD4 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5291783

实验名称：Binding affinity towards human EDNRB in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Endothelin receptor type B External Id：CHEMBL5291786

实验名称：Binding affinity towards human EDNRA in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Endothelin-1 receptor External Id：CHEMBL5291785

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

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伊普吲哚英文别名

• Prondol
• Iprindole
• Galatur
• Pramindole
• WY-3263
• Tertran