TCN 213
Modify Date: 2024-01-17 09:44:03
TCN 213 structure
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Common Name | TCN 213 | ||
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| CAS Number | 556803-08-8 | Molecular Weight | 376.53900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H24N4OS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TCN 213TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2]. |
| Name | 2-{[5-(Benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(cyclohexyl methyl)acetamide |
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| Description | TCN 213 is a selective, surmountable, glycine-dependentlly GluN1/GluN2A NMDAR antagonist with IC50s of 0.55, 3.5, 40 μM in the presence of 75, 750, 7500 nM glycine, respectively. TCN 213 can be used to monitor, pharmacologically, the switch in NMDAR expression in developing cortical neurones[1][2]. |
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| Related Catalog | |
| Target |
GluN1/GluN2A NMDAR:0.55-40 μM (IC50) |
| In Vitro | TCN 213 (30 µM) antagonizes NMDA-evoked currents in neurones transfected with GluN2A subunits[1]. |
| References |
| Molecular Formula | C18H24N4OS2 |
|---|---|
| Molecular Weight | 376.53900 |
| Exact Mass | 376.13900 |
| PSA | 127.17000 |
| LogP | 4.20100 |
| Hazard Codes | Xi |
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| HS Code | 2934999090 |
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |