Trimethylapigenin

Modify Date: 2024-01-09 23:22:26

Trimethylapigenin structure	Common Name	Trimethylapigenin
	CAS Number	5631-70-9	Molecular Weight	312.31700
	Density	1.242g/cm3	Boiling Point	506.5ºC at 760mmHg
	Molecular Formula	C₁₈H₁₆O₅	Melting Point	158-160ºC (dec.)
	MSDS	N/A	Flash Point	225.5ºC

Use of Trimethylapigenin

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].

Name	5,7-dimethoxy-2-(4-methoxyphenyl)chromen-4-one
Synonym	More Synonyms

Description	5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a concentration dependent manner[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	Caspase-3 PARP
References	[1]. Kim H, et al. Induction of ER Stress-Mediated Apoptosis by the Major Component 5,7,4'-TrimethoxyflavoneIsolated from Kaempferia parviflora Tea Infusion. Nutr Cancer. 2018 Aug-Sep;70(6):984-996.

Density	1.242g/cm3
Boiling Point	506.5ºC at 760mmHg
Melting Point	158-160ºC (dec.)
Molecular Formula	C₁₈H₁₆O₅
Molecular Weight	312.31700
Flash Point	225.5ºC
Exact Mass	312.10000
PSA	57.90000
LogP	3.48580
Index of Refraction	1.585

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%