tirotundin

Modify Date: 2024-01-11 15:16:51

tirotundin Structure
tirotundin structure
Common Name tirotundin
CAS Number 56377-67-4 Molecular Weight 352.42
Density 1.2±0.1 g/cm3 Boiling Point 493.6±45.0 °C at 760 mmHg
Molecular Formula C19H28O6 Melting Point N/A
MSDS N/A Flash Point 171.1±22.2 °C

 Use of tirotundin


Tirotundin (Tagitinin D) is a potent anti-inflammatory agent. Tirotundin inhibits the activation of NF-Kβ[1].

 Names

Name Tirotundine
Synonym More Synonyms

 tirotundin Biological Activity

Description Tirotundin (Tagitinin D) is a potent anti-inflammatory agent. Tirotundin inhibits the activation of NF-Kβ[1].
Related Catalog
In Vitro Tirotundin (compound 3) (5, 10, 20, 50 µM; 1 h;随后用 TNF-α 刺激一小时) 在浓度为 50 µM 时完全抑制 NF-Kβ 的激活[1]。
References

[1]. Rüngeler P, et al. Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets. Planta Med. 1998 Oct;64(7):588-93.  

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 493.6±45.0 °C at 760 mmHg
Molecular Formula C19H28O6
Molecular Weight 352.42
Flash Point 171.1±22.2 °C
Exact Mass 352.188599
PSA 82.06000
LogP 1.86
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.528

 Safety Information

Hazard Codes Xi

 Synonyms

Propanoic acid, 2-methyl-, (3aS,4R,6S,9R,10S,11aR)-dodecahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester
Titrotundine
TAGITININ-D
(1R,2S,4R,8S,9R,11S)-1-Hydroxy-2,11-dimethyl-7-methylene-6-oxo-5,14-dioxatricyclo[9.2.1.0]tetradec-9-yl 2-methylpropanoate