THDOC
THDOC structure
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Common Name | THDOC | ||
|---|---|---|---|---|
| CAS Number | 567-02-2 | Molecular Weight | 334.49300 | |
| Density | 1.115g/cm3 | Boiling Point | 470.3ºC at 760mmHg | |
| Molecular Formula | C21H34O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 252.3ºC | |
Use of THDOC3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. |
| Name | 2-hydroxy-1-[(8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone |
|---|---|
| Synonym | More Synonyms |
| Description | 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro. |
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| Related Catalog |
| Density | 1.115g/cm3 |
|---|---|
| Boiling Point | 470.3ºC at 760mmHg |
| Molecular Formula | C21H34O3 |
| Molecular Weight | 334.49300 |
| Flash Point | 252.3ºC |
| Exact Mass | 334.25100 |
| PSA | 57.53000 |
| LogP | 3.56760 |
| Index of Refraction | 1.54 |
| InChIKey | CYKYBWRSLLXBOW-GDYGHMJCSA-N |
| SMILES | CC12CCC(O)CC1CCC1C2CCC2(C)C(C(=O)CO)CCC12 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
CAS#:516-54-1
CAS#:516-55-2
CAS#:566-65-4![tert-butyl((1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)vinyl)oxy)dimethylsilane Structure](https://image.chemsrc.com/caspic/158/225518-89-8.png)
CAS#:225518-89-8|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc... |
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A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 976-977 , 6-18, (2015) Free arachidonic acid is functionally interlinked with different lipid signaling networks including those involving prostanoid pathways, the endocannabinoid system, N-acylethanolamines, as well as ste... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened... |
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Concentration required to potentiate GABA-evoked currents in voltage-clamped bovine c...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-4
External Id: CHEMBL659786
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Name: Human GABAA receptor alpha5 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha5 subunit (GABAA receptors) [Homo sapiens]
External Id: 408_Human
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Name: The recovery of radioactivity 20 min after administration of [3H]- labeled steroids t...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL789038
|
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Name: The recovery of radioactivity 20 min after administration of [3H]- labeled steroids t...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL789037
|
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Name: Human GABAA receptor alpha1 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha1 subunit (GABAA receptors) [Homo sapiens]
External Id: 404_Human
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Name: Percent of total tritium in extracts of rat brain
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL796241
|
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Name: Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia c...
Source: ChEMBL
Target: Glucose-6-phosphate 1-dehydrogenase
External Id: CHEMBL2061901
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Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Human GABAA receptor alpha3 subunit (GABAA receptors)
Source: IUPHAR-DB
Target: GABAA receptor alpha3 subunit (GABAA receptors) [Homo sapiens]
External Id: 406_Human
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