THDOC

Modify Date: 2024-01-02 18:19:37

THDOC Structure
THDOC structure
Common Name THDOC
CAS Number 567-02-2 Molecular Weight 334.49300
Density 1.115g/cm3 Boiling Point 470.3ºC at 760mmHg
Molecular Formula C21H34O3 Melting Point N/A
MSDS Chinese USA Flash Point 252.3ºC

 Use of THDOC


3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.

 Names

Name 2-hydroxy-1-[(8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Synonym More Synonyms

 THDOC Biological Activity

Description 3α,21-Dihydroxy-5α-pregnan-20-one (THDOC), an endogenous neurosteroid, is a positive modulator of GABAA receptors. 3α,21-Dihydroxy-5α-pregnan-20-one potentiates neuronal response to low concentrations of GABA at α4β1δ GABAA receptors in vitro.
Related Catalog

 Chemical & Physical Properties

Density 1.115g/cm3
Boiling Point 470.3ºC at 760mmHg
Molecular Formula C21H34O3
Molecular Weight 334.49300
Flash Point 252.3ºC
Exact Mass 334.25100
PSA 57.53000
LogP 3.56760
Index of Refraction 1.54

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles32

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Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

 Synonyms

[3H]-Allotetrahydrodeoxycorticosterone
21-HYDROXYALLOPREGNANOLONE
TDOC
ALLOTETRADEOXYCORTICOSTERONE
ALLOTETRAHYDRO DOC
ALLOTETRAHYDRO SUBSTANCE 'Q'
ALLOTETRAHYDRODEOXYCORTICOSTERONE
ALLOTETRAHYDROCORTEXONE
ALLO TH DOC
5A-pregnane-3A,21-diol-20-one
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