Alloepipregnanolone
Modify Date: 2025-08-21 03:01:23
Alloepipregnanolone structure
|
Common Name | Alloepipregnanolone | ||
|---|---|---|---|---|
| CAS Number | 516-55-2 | Molecular Weight | 318.49300 | |
| Density | 1.053g/cm3 | Boiling Point | 431.2ºC at 760mmHg | |
| Molecular Formula | C21H34O2 | Melting Point | 200℃ | |
| MSDS | N/A | Flash Point | 183.9ºC | |
Use of AlloepipregnanoloneAlloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol. |
| Name | 3β-hydroxy-5α-pregnan-20-one |
|---|---|
| Synonym | More Synonyms |
| Description | Alloepipregnanolone, a pregnane with anesthetic, hypnotic, and sedative properties, interferes with the development of rapid tolerance to the anxiolytic effect of ethanol. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vivo | On day 2, pretreatment with a 0.20 mg/kg dose of Alloepipregnanolone blocks the development of rapid tolerance to the anxiolytic effect of ethanol. However, there is a significant decrease in the anxiolytic effect in the control groups that received ethanol on both days (EE), suggesting that the 1.5 g/kg dose of ethanol results in rapid tolerance. The post hoc analysis confirms that the 0.20 mg/kg pretreatment with Alloepipregnanolone blocks the rapid tolerance compared to the control groups, although the 0.10 mg/kg dose only partially blocks the development of such tolerance. However, the 0.05 mg/kg dose has no effect on the development of rapid tolerance to ethanol[1]. |
| Animal Admin | Mice[1] Male Swiss mice are pretreated with Alloepipregnanolone (isopregnanolone: 0.05, 0.10 or 0.20 mg/kg) 30 min before administration of ethanol (1.5 g/kg). Twenty-four hours later, all animals tested using the plus-maze apparatus. The first experiment defines the doses of ethanol that does or does not induce rapid tolerance to the anxiolytic effect of ethanol. In the second, the influence of pretreatment of mice with Alloepipregnanolone (0.05, 0.10 or 0.20 mg/kg) on rapid tolerance to ethanol (1.5 g/kg) is studied[1]. |
| References |
| Density | 1.053g/cm3 |
|---|---|
| Boiling Point | 431.2ºC at 760mmHg |
| Melting Point | 200℃ |
| Molecular Formula | C21H34O2 |
| Molecular Weight | 318.49300 |
| Flash Point | 183.9ºC |
| Exact Mass | 318.25600 |
| PSA | 37.30000 |
| LogP | 4.59520 |
| Index of Refraction | 1.524 |
| InChIKey | AURFZBICLPNKBZ-FZCSVUEKSA-N |
| SMILES | CC(=O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| RTECS | TU4383200 |
|---|
| Precursor 10 | |
|---|---|
| DownStream 6 | |
CAS#:145-13-1
CAS#:1162-53-4
CAS#:906-83-2![1-((3S,5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-3-((tetrahydrofuran-2-yl)oxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone Structure](https://image.chemsrc.com/caspic/047/111222-35-6.png)
CAS#:111222-35-6
CAS#:979-02-2
CAS#:1778-02-5
CAS#:566-65-4
CAS#:57-83-0
CAS#:17182-23-9
CAS#:73230-77-0
CAS#:567-02-2
CAS#:481-29-8
CAS#:26654-59-1
CAS#:1239-31-2
CAS#:6010-85-1|
Name: Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia c...
Source: ChEMBL
Target: Glucose-6-phosphate 1-dehydrogenase
External Id: CHEMBL2061901
|
|
Name: Potentiation of NAS mediated GABA (unknown origin) tonic effect assessed as fold pote...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit gamma-2
External Id: CHEMBL5263755
|
|
Name: Anticonvulsant activity in 6-Hz induced seizure mouse model assessed as protection ag...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL5263754
|
|
Name: Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening
Source: 11827
Target: Phosphogluconate dehydrogenase
External Id: 6PGD_Inhibitor_Screening_2015_09
|
Total 4, Current Page 1 of 1
1
| ALLOPREGNAN-3B-OL-20-ONE |
| 3beta-hydroxy-5alpha-pregnan-20-one |
| 3-Hydroxypregnan-20-one |
| Alloepipregnanolone |
| 5A-PREGNAN-3B-OL-20-ONE |
| Tetrahydroprogesterone |
| ALLOPREGNANOLONE |
| ISOPREGNANOLONE |
| EINECS 208-224-2 |
| MFCD00064935 |
| epi-allopregnanolone |