Zimeldine

Modify Date: 2025-08-25 11:12:56

Zimeldine structure	Common Name	Zimeldine
	CAS Number	56775-88-3	Molecular Weight	317.224
	Density	1.3±0.1 g/cm3	Boiling Point	412.8±45.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₉BrCl₂N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	203.4±28.7 °C

Use of Zimeldine

Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant[1][2][3][4].

Name	Zimelidine dihydrochloride,(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine
Synonym	More Synonyms

Description	Zimelidine is a potent and selective inhibitor of serotonin 5-HT uptake and SERT. Zimelidine is an antidepressant[1][2][3][4].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vivo	Zimelidine (15 mg/kg, IP, once) reduces the development of tolerance to morphine-induced antinociception in rats[3]. Zimelidine (5 mg/kg, IP, daily for 14 days) dose not modify the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT[2]. Zimelidine (0.2, 2 and 20 nmol/100 nL) in medial amygdaloid nucleus (MeA) evokes dose dependent hypophagic effects in fasted rats[4]. Animal Model: Male Wistar albino rats (160-180 g, n=72)[3] Dosage: 15 mg/kg Administration: IP, once Result: Significantly attenuated the development and expression of morphine tolerance. The maximal antinociceptive effect of Zimelidine was obtained at the 60 minutes measurements in the zimelidine group and at the 30 minutes measurements in the morphine tolerant group by the tail-flick and hot-plate tests. Administration of zimelidine with morphine showed additive analgesic effect. Animal Model: Sprague-Dawley rats (150 to 250 g, Ten, male)[2] Dosage: 5 mg/kg Administration: IP, daily for 14 days Result: Did not modify the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoreticahy applied 5-HT.
References	[1]. Heel RC, et al. Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1982 Sep;24(3):169-206. [2]. Blier P, et al. Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci. 1983 Jun;3(6):1270-8. [3]. Ozdemir E, et al. Zimelidine attenuates the development of tolerance to morphine-induced antinociception. Indian J Pharmacol. 2012 Mar;44(2):215-8. [4]. Scopinho AA, et al. Medial amygdaloid nucleus 5-HT₂c receptors are involved in the hypophagic effect caused by zimelidine in rats. Neuropharmacology. 2012 Aug;63(2):301-9.

Density	1.3±0.1 g/cm3
Boiling Point	412.8±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₉BrCl₂N₂
Molecular Weight	317.224
Flash Point	203.4±28.7 °C
Exact Mass	316.057495
PSA	16.13000
LogP	4.63
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.597

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC6555000

CHEMICAL NAME :: 2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-

CAS REGISTRY NUMBER :: 56775-88-3

BEILSTEIN REFERENCE NO. :: 0479680

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H17-Br-N2

MOLECULAR WEIGHT :: 317.26

WISWESSER LINE NOTATION :: T6NJ CYR DE&U2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 56 mg/kg/14D

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - headache Gastrointestinal - nausea or vomiting

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 285,1009,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic

REFERENCE :: DRUGAY Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. (ADIS Press International Inc., Suite B-30, Oxford Ct. Business Center, 582 Middletown Blvd., Langhorne, PA 19047) V.1- 1971- Volume(issue)/page/year: 24,169,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 280 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: NEAGDO Neurobiology of Aging. (ANKHO International Inc., POB 426, Fayetteville, NY 13066) V.1- 1980- Volume(issue)/page/year: 7,9,1986

Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	S36

Precursor 10
CAS#:506-59-2 Dimethylamine h... CAS#:77470-68-9 3-(4-bromopheny... CAS#:14548-45-9 3-(4-BROMOBENZO... CAS#:77744-36-6 (Z)-3-Acetoxy-1...
CAS#:124-40-3 Dimethylamine CAS#:77744-18-4 1-(4-bromopheny... CAS#:70263-43-3 alpha-(4-bromop... CAS#:10400-19-8 Nicotinoyl chloride
CAS#:108-86-1 Bromobenzene CAS#:77470-73-6 (Z)-3-(4-bromop...
DownStream 3
CAS#:77470-68-9 3-(4-bromopheny... CAS#:60324-59-6 Nomelidine CAS#:60324-67-6 3-(4-bromopheny...

2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (2Z)-

Normud

cis-H-102/09

cis-H 102/09

Hydrochloride,zimeldine

(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(pyridin-3-yl)prop-2-en-1-amine

H-102/09

Zimeldine

2-Propen-1-amine, 3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-, (Z)-

Zelmid

Zimelidine

(Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine

cis-Zimelidine

(2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Zimelidine
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Zimelidine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ZIMELIDINE DIHYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Zimeldine suppliers

Zimeldine price