nalorphine hydrochloride ciii (250 mg)

Modify Date: 2025-08-25 13:01:05

nalorphine hydrochloride ciii (250 mg) structure	Common Name	nalorphine hydrochloride ciii (250 mg)
	CAS Number	57-29-4	Molecular Weight	347.83600
	Density	N/A	Boiling Point	493.6ºC at 760 mmHg
	Molecular Formula	C₁₉H₂₂ClNO₃	Melting Point	208ºC
	MSDS	N/A	Flash Point	11ºC
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Name	(4R,4aR,7S,7aR,12bS)-3-prop-2-enyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol,hydrochloride
Synonym	More Synonyms

Boiling Point	493.6ºC at 760 mmHg
Melting Point	208ºC
Molecular Formula	C₁₉H₂₂ClNO₃
Molecular Weight	347.83600
Flash Point	11ºC
Exact Mass	347.12900
PSA	52.93000
LogP	2.49420
Appearance of Characters	solid \| white
InChIKey	NAHATSPWSULUAA-ZQGPYOJVSA-N
SMILES	C=CCN1CCC23c4c5ccc(O)c4OC2C(O)C=CC3C1C5.Cl
Storage condition	2-8°C
Water Solubility	H2O: slightly soluble

nalorphine hydrochloride ciii (250 mg) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QC7710000

CHEMICAL NAME :: Morphinan-3,6-alpha-diol, 17-allyl-7,8-didehydro-4,5-alpha-epoxy-, hydrochloride

CAS REGISTRY NUMBER :: 57-29-4

LAST UPDATED :: 199306

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C19-H21-N-O3.Cl-H

MOLECULAR WEIGHT :: 347.87

WISWESSER LINE NOTATION :: T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ JQ P2U1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 143 ug/kg

TOXIC EFFECTS :: Behavioral - euphoria Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis

REFERENCE :: AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921- Volume(issue)/page/year: 113,887,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,48,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 447 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 103,489,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 505 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,593,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 111,152,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - analgesia

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,571,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 350 mg/kg

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 14,481,1967

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	Xn,T,F
Risk Phrases	22-39/23/24/25-23/24/25-11
Safety Phrases	36/37/39-45-36/37-16-7
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS	QC7710000

Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography.

BMC Res. Notes 5 , 439, (2012)

Naltrexone has been proven to be an effective treatment option for the treatment of alcohol dependency. In this article we introduce a reliable and simple method developed for the simultaneous determi...

GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine.

J. Anal. Toxicol. 23(3) , 177-86, (1999)

A procedure for the simultaneous confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine specimens by gas chromatography-mass spectrometry ...

Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds.

Drug Metab. Dispos. 25(2) , 251-5, (1997)

Opioids are important drugs used as analgesics, antitussives, antidiarrheals, and in the therapy of myocardial infarctions, and as antagonists of opioid intoxication. The glucuronidation of these comp...

Name: Physical dependence capacity in monkey assessed as single dose suppression of morphin...
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL3279403

Name: Analgesic activity in sc dosed mouse by Nilsen assay
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3279402

Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signa...
Source: 824
Target: AR protein [Homo sapiens]
External Id: MDAN535

Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100

Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101

Name: Analgesic activity in sc dosed mouse assessed as reduction in phenylalanine-induced w...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL3282835

Name: qHTS assay to identify small molecule antagonists of the androgen receptor (AR) sign...
Source: 824
Target: N/A
External Id: MDAV150

Name: Compound administered subcutaneously was evaluated for Opioid antagonist activity ver...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL730048

Name: Analgesic activity in sc dosed rat by tail flick test
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL3282836

Name: qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cel...
Source: 824
Target: RecName: Full=ATPase family AAA domain-containing protein 5; AltName: Full=Chromosome fragility-associated gene 1 protein
External Id: ELG271

Total 89, Current Page 1 of 9

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DEA No. 9400

Nalline

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nalorphine hydrochloride ciii (250 mg)

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Articles25

nalorphine hydrochloride ciii (250 mg)Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.