11-Maleimidoundecanoic acid

Modify Date: 2024-01-04 18:11:21

11-Maleimidoundecanoic acid Structure
11-Maleimidoundecanoic acid structure
Common Name 11-Maleimidoundecanoic acid
CAS Number 57079-01-3 Molecular Weight 281.347
Density 1.1±0.1 g/cm3 Boiling Point 452.8±18.0 °C at 760 mmHg
Molecular Formula C15H23NO4 Melting Point 89-90ºC
MSDS Chinese USA Flash Point 227.6±21.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 11-Maleimidoundecanoic acid


11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 11-(2,5-dioxopyrrol-1-yl)undecanoic acid
Synonym More Synonyms

 11-Maleimidoundecanoic acid Biological Activity

Description 11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 452.8±18.0 °C at 760 mmHg
Melting Point 89-90ºC
Molecular Formula C15H23NO4
Molecular Weight 281.347
Flash Point 227.6±21.2 °C
Exact Mass 281.162720
PSA 74.68000
LogP 3.36
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.515
Storage condition -20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2925190090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2925190090
Summary 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles2

More Articles
Synthesis of Heterotelechelic Polymers for Conjugation of Two Different Proteins.

Macromolecules 42 , 2360, (2009)

In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(N-isopropylacrylam...

Safak, M.; Alemdaroglu, F. E.; Li, Y.; Ergen, E.; Hernnann, A.

Adv. Mater. 19 , 1499, (2007)

 Synonyms

11-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)undecanoic acid
11-maleimido-undecanoic acid
1H-Pyrrole-1-undecanoic acid, 2,5-dihydro-2,5-dioxo-
UNII-LG78EY7HVB
maleimidoundecanoic acid