Maleimide-C10-NHS ester

Modify Date: 2024-01-09 21:34:48

Maleimide-C10-NHS ester Structure
Maleimide-C10-NHS ester structure
Common Name Maleimide-C10-NHS ester
CAS Number 87981-04-2 Molecular Weight 378.419
Density 1.3±0.1 g/cm3 Boiling Point 520.4±42.0 °C at 760 mmHg
Molecular Formula C19H26N2O6 Melting Point N/A
MSDS N/A Flash Point 268.5±27.9 °C

 Use of Maleimide-C10-NHS ester


Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 11-Maleimidoundecanoic Acid N-Succinimidyl Ester
Synonym More Synonyms

 Maleimide-C10-NHS ester Biological Activity

Description Maleimide-C10-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 520.4±42.0 °C at 760 mmHg
Molecular Formula C19H26N2O6
Molecular Weight 378.419
Flash Point 268.5±27.9 °C
Exact Mass 378.179077
PSA 101.06000
LogP 1.84
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.552

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26-36
WGK Germany 3

 Synonyms

(2,5-dioxopyrrolidin-1-yl) 11-(2,5-dioxopyrrol-1-yl)undecanoate
1-{11-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-11-oxoundecyl}-1H-pyrrole-2,5-dione
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