Androstan-17-one,3-hydroxy-, (3b,5b)-

Modify Date: 2024-01-01 20:43:08

Androstan-17-one,3-hydroxy-, (3b,5b)- structure	Common Name	Androstan-17-one,3-hydroxy-, (3b,5b)-
	CAS Number	571-31-3	Molecular Weight	290.44000
	Density	1.085 g/cm3	Boiling Point	413.1ºC at 760 mmHg
	Molecular Formula	C₁₉H₃₀O₂	Melting Point	154-156ºC
	MSDS	N/A	Flash Point	176.4ºC

Use of Androstan-17-one,3-hydroxy-, (3b,5b)-

5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2].

Name	(3S,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
Synonym	More Synonyms

Description	5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vivo	5β-Androstan-3β-ol-17-one (2 mg/mouse; 皮下注射; 每天 1 次, 共 4 周) 缺乏任何有益的影响，这表明这些代谢物需要一些生物转化才能完全有效[1]。 5β-Androstan-3β-ol-17-one (添加饲料中, 质量比分别为 0.025%, 0.05%, 0.1%; 口服; 共 18 周) 在小鼠中，防止严重糖尿病的发生，调节高血糖状态正常化，同时对进食量或体重增加率无影响[1]。 5β-Androstan-3β-ol-17-one (1 mg/kg-20 mg/kg; 静脉注射; 单剂量) 在高剂量下，对成年公猫的神经元有强烈的抑制作用[2]。 Animal Model: C57BL/KsJ genetically diabetic (db/db) mice model[1] Dosage: 0.025%, 0.05%, 0.1% in diet Administration: Oral gavage; filled the diet every second day; for 18 weeks Result: Exerted strong antihyperglycemic effects.
References	[1]. Coleman DL, et al. Therapeutic effects of dehydroepiandrosterone metabolites in diabetes mutant mice (C57BL/KsJ-db/db). Endocrinology. 1984 Jul;115(1):239-43. [2]. Kubli-Garfias C, et al. Depressant effect of androgens on the cat brain electrical activity and its antagonism by ruthenium red. Neuroscience. 1982;7(11):2777-82.

Density	1.085 g/cm3
Boiling Point	413.1ºC at 760 mmHg
Melting Point	154-156ºC
Molecular Formula	C₁₉H₃₀O₂
Molecular Weight	290.44000
Flash Point	176.4ºC
Exact Mass	290.22500
PSA	37.30000
LogP	3.95910
Index of Refraction	1.536

Precursor 6
CAS#:1229-12-5 5B-ANDROSTANE-3... CAS#:5717-77-1 (3β,5α)-3-hydro... CAS#:571-20-0 5α-Androstane-3... CAS#:2943-02-4 2β-Methoxycarbo...
CAS#:2943-04-6 3β-hydroxy-16,1... CAS#:80-97-7 Dihydrocholesterol
DownStream 0