571-31-3
571-31-3 structure
- Name: Androstan-17-one,3-hydroxy-, (3b,5b)-
- Chemical Name: (3S,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
- CAS Number: 571-31-3
- Molecular Formula: C19H30O2
- Molecular Weight: 290.44000
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-12-02 18:55:09
- Modify Date: 2024-01-01 20:43:08
-
5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2].
| Name | (3S,5R,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one |
|---|---|
| Synonyms |
Epiaetiocholanolone
Epietiocholanolone 3b-hydroxy-5b-androstan-17-one epi-5b-Androsterone b-Etiocholanolone 3b-Etiocholanolone 5b-Epiandrosterone |
| Description | 5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a steroid with 5β reduction, is one the major metabolic products of ehydroepiandrosterone (DHEA). 5β-Androstan-3β-ol-17-one exert strong antihyperglycemic effects in C57BL/KsJ genetically diabetic (db/db) mice. 5β-Androstan-3β-ol-17-one also exerts depressive effect on neurons[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | 5β-Androstan-3β-ol-17-one (2 mg/mouse; 皮下注射; 每天 1 次, 共 4 周) 缺乏任何有益的影响，这表明这些代谢物需要一些生物转化才能完全有效[1]。 5β-Androstan-3β-ol-17-one (添加饲料中, 质量比分别为 0.025%, 0.05%, 0.1%; 口服; 共 18 周) 在小鼠中，防止严重糖尿病的发生，调节高血糖状态正常化，同时对进食量或体重增加率无影响[1]。 5β-Androstan-3β-ol-17-one (1 mg/kg-20 mg/kg; 静脉注射; 单剂量) 在高剂量下，对成年公猫的神经元有强烈的抑制作用[2]。 Animal Model: C57BL/KsJ genetically diabetic (db/db) mice model[1] Dosage: 0.025%, 0.05%, 0.1% in diet Administration: Oral gavage; filled the diet every second day; for 18 weeks Result: Exerted strong antihyperglycemic effects. |
| References |
| Density | 1.085 g/cm3 |
|---|---|
| Boiling Point | 413.1ºC at 760 mmHg |
| Melting Point | 154-156ºC |
| Molecular Formula | C19H30O2 |
| Molecular Weight | 290.44000 |
| Flash Point | 176.4ºC |
| Exact Mass | 290.22500 |
| PSA | 37.30000 |
| LogP | 3.95910 |
| Index of Refraction | 1.536 |
