Methenamine hippurate

Modify Date: 2024-01-05 18:24:07

Methenamine hippurate Structure
Methenamine hippurate structure
 Common Name Methenamine hippurate
CAS Number 5714-73-8 Molecular Weight 319.35900
Density N/A Boiling Point 464.1ºC at 760mmHg
Molecular Formula C15H21N5O3 Melting Point 89-95ºC
MSDS N/A Flash Point 234.5ºC

 Use of Methenamine hippurate


Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].

 Names

Name Hiprex
Synonym More Synonyms

 Methenamine hippurate Biological Activity

Description Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].
Related Catalog
In Vitro Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli, Staphylococcus aureus, Aerobacter aeroaenes, Pseudomonas aeruginosa and Proteus vulgaris, and a wide range of action against Klebsiella pneumoniae, Ps. aeruginosa, E. coli, Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine[1].
References

[1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 2018 Nov 9.

[2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170.

 Chemical & Physical Properties

Boiling Point 464.1ºC at 760mmHg
Melting Point 89-95ºC
Molecular Formula C15H21N5O3
Molecular Weight 319.35900
Flash Point 234.5ºC
Exact Mass 319.16400
PSA 79.36000
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MR8159000
CAS REGISTRY NUMBER :
5714-73-8
LAST UPDATED :
199504
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H9-N-O3.C6-H12-N4
MOLECULAR WEIGHT :
319.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2870 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82903 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82903 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

 Safety Information

Hazard Codes Xi
RIDADR NONH for all modes of transport

 Synonyms

Hippramine
Hexamethylenetetramine hippurate
R-657
Haiprex
Hexamethylenetetramine monohippurate
Viapta
hexamine hippurate
Methenamine hippurate
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