Methenamine hippurate

Modify Date: 2024-01-05 18:24:07

Methenamine hippurate structure	Common Name	Methenamine hippurate
	CAS Number	5714-73-8	Molecular Weight	319.35900
	Density	N/A	Boiling Point	464.1ºC at 760mmHg
	Molecular Formula	C₁₅H₂₁N₅O₃	Melting Point	89-95ºC
	MSDS	N/A	Flash Point	234.5ºC

Use of Methenamine hippurate

Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].

Name	Hiprex
Synonym	More Synonyms

Description	Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli, Staphylococcus aureus, Aerobacter aeroaenes, Pseudomonas aeruginosa and Proteus vulgaris, and a wide range of action against Klebsiella pneumoniae, Ps. aeruginosa, E. coli, Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine[1].
References	[1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 2018 Nov 9. [2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170.

Boiling Point	464.1ºC at 760mmHg
Melting Point	89-95ºC
Molecular Formula	C₁₅H₂₁N₅O₃
Molecular Weight	319.35900
Flash Point	234.5ºC
Exact Mass	319.16400
PSA	79.36000
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MR8159000

CAS REGISTRY NUMBER :: 5714-73-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H9-N-O3.C6-H12-N4

MOLECULAR WEIGHT :: 319.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2870 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82903 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82903 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Hippramine

Hexamethylenetetramine hippurate

R-657

Haiprex

Hexamethylenetetramine monohippurate

Viapta

hexamine hippurate

Methenamine hippurate

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Methenamine hippurate
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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