Top Suppliers:I want be here

5714-73-8

5714-73-8 structure
5714-73-8 structure
  • Name: Methenamine hippurate
  • Chemical Name: Hiprex
  • CAS Number: 5714-73-8
  • Molecular Formula: C15H21N5O3
  • Molecular Weight: 319.35900
  • Catalog: API Synthetic anti-infective drugs Nitrofuran
  • Create Date: 2018-03-01 08:00:00
  • Modify Date: 2024-01-05 18:24:07
  • Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].

Name Hiprex
Synonyms Hippramine
Hexamethylenetetramine hippurate
R-657
Haiprex
Hexamethylenetetramine monohippurate
Viapta
hexamine hippurate
Methenamine hippurate
Description Methenamine hippurate (Hexamine hippurate) is an orally active urinary antiseptic agent with a wide antibacterial spectrum. Methenamine hippurate is effective against most common urinary tract pathogens[1][2].
Related Catalog
In Vitro Methenamine hippurate is a urinary antibacterial agent which releases formaldehyde and is excreted in the urine. Methenamine hippurate has a demonstrable activity in vitro at pH 5 to 6 against Escherichia coli, Staphylococcus aureus, Aerobacter aeroaenes, Pseudomonas aeruginosa and Proteus vulgaris, and a wide range of action against Klebsiella pneumoniae, Ps. aeruginosa, E. coli, Staph. aureus and Streptococcus haemolytic at pH of 7.4. This action is more effective than that of Methenamine alone, of Hippuric acid alone or of Sulphadiazine[1].
References

[1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 2018 Nov 9.

[2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170.

Boiling Point 464.1ºC at 760mmHg
Melting Point 89-95ºC
Molecular Formula C15H21N5O3
Molecular Weight 319.35900
Flash Point 234.5ºC
Exact Mass 319.16400
PSA 79.36000
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MR8159000
CAS REGISTRY NUMBER :
5714-73-8
LAST UPDATED :
199504
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H9-N-O3.C6-H12-N4
MOLECULAR WEIGHT :
319.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2870 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82903 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82903 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)
Hazard Codes Xi
RIDADR NONH for all modes of transport