N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE structure
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Common Name | N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE | ||
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| CAS Number | 57159-62-3 | Molecular Weight | 307.09800 | |
| Density | 1.69 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H11BrN2O5 | Melting Point | 93-94ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATEN-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N-Succinimidyl 3-(Bromoacetamido)propionate |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | |
| Target |
PEGs Alkyl/ether Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.69 g/cm3 |
|---|---|
| Melting Point | 93-94ºC |
| Molecular Formula | C9H11BrN2O5 |
| Molecular Weight | 307.09800 |
| Exact Mass | 305.98500 |
| PSA | 92.78000 |
| Index of Refraction | 1.566 |
| InChIKey | WGMMKWFUXPMTRW-UHFFFAOYSA-N |
| SMILES | O=C(CBr)NCCC(=O)ON1C(=O)CCC1=O |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| HS Code | 2925190090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~50%
N-SUCCINIMIDYL ... CAS#:57159-62-3 |
| Literature: Zaitsu; Ohnishi; Hosoya; Sugimoto; Ohkura Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1991 - 1997 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: Polar surface area (PSA) of N-Succinimidyl 3-(Bromoacetamido)propionate is 92.78000. |
| Q: What is the InChIKey of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: InChIKey of N-Succinimidyl 3-(Bromoacetamido)propionate is WGMMKWFUXPMTRW-UHFFFAOYSA-N. |
| Q: What English synonyms does N-Succinimidyl 3-(Bromoacetamido)propionate have? |
| A: English synonyms of N-Succinimidyl 3-(Bromoacetamido)propionate: (2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate. |
| Q: What are the uses of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: Main uses of N-Succinimidyl 3-(Bromoacetamido)propionate: N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Q: What is the molecular weight of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: Molecular weight of N-Succinimidyl 3-(Bromoacetamido)propionate is 307.09800. |
| Q: What is the English name of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: The English name of N-Succinimidyl 3-(Bromoacetamido)propionate is N-Succinimidyl 3-(Bromoacetamido)propionate. |
| Q: What is the SMILES notation of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: SMILES notation of N-Succinimidyl 3-(Bromoacetamido)propionate is O=C(CBr)NCCC(=O)ON1C(=O)CCC1=O. |
| Q: What is the CAS number of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: CAS number of N-Succinimidyl 3-(Bromoacetamido)propionate is 57159-62-3. |
| Q: What are the upstream materials of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: Related upstream materials(CAS) of N-Succinimidyl 3-(Bromoacetamido)propionate: 6066-82-6;89520-11-6. |
| Q: What is the molecular formula of N-Succinimidyl 3-(Bromoacetamido)propionate? |
| A: Molecular formula of N-Succinimidyl 3-(Bromoacetamido)propionate is C9H11BrN2O5. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |