N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE
Modify Date: 2024-01-08 13:49:53
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE structure
|
Common Name | N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE | ||
|---|---|---|---|---|
| CAS Number | 57159-62-3 | Molecular Weight | 307.09800 | |
| Density | 1.69 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C9H11BrN2O5 | Melting Point | 93-94ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATEN-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | N-Succinimidyl 3-(Bromoacetamido)propionate |
|---|---|
| Synonym | More Synonyms |
| Description | N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Alkyl/ether Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Density | 1.69 g/cm3 |
|---|---|
| Melting Point | 93-94ºC |
| Molecular Formula | C9H11BrN2O5 |
| Molecular Weight | 307.09800 |
| Exact Mass | 305.98500 |
| PSA | 92.78000 |
| Index of Refraction | 1.566 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2925190090 |
|
~50%
N-SUCCINIMIDYL ... CAS#:57159-62-3 |
| Literature: Zaitsu; Ohnishi; Hosoya; Sugimoto; Ohkura Chemical and pharmaceutical bulletin, 1987 , vol. 35, # 5 p. 1991 - 1997 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
| (2,5-dioxopyrrolidin-1-yl) 3-[(2-bromoacetyl)amino]propanoate |