N-Bromoacetyl-β-alanine

Modify Date: 2025-08-26 17:09:42

N-Bromoacetyl-β-alanine structure	Common Name	N-Bromoacetyl-β-alanine
	CAS Number	89520-11-6	Molecular Weight	210.02600
	Density	1.682g/cm3	Boiling Point	433.4ºC at 760 mmHg
	Molecular Formula	C₅H₈BrNO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	215.9ºC

Use of N-Bromoacetyl-β-alanine

N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	3-[(2-bromoacetyl)amino]propanoic acid
Synonym	More Synonyms

Description	N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Density	1.682g/cm3
Boiling Point	433.4ºC at 760 mmHg
Molecular Formula	C₅H₈BrNO₃
Molecular Weight	210.02600
Flash Point	215.9ºC
Exact Mass	208.96900
PSA	69.89000
LogP	0.81250
Index of Refraction	1.523
InChIKey	ULKDIPSSLZFIQU-UHFFFAOYSA-N
SMILES	O=C(O)CCNC(=O)CBr

Hazard Codes	Xi

3-(2-bromo-acet...

CAS#:614760-41-7

N-Bromoacetyl-β...

CAS#:89520-11-6

Literature: Erlanson, Daniel A.; McDowell, Robert S.; He, Molly M.; Randal, Mike; Simmons, Robert L.; Kung, Jenny; Waight, Andrew; Hansen, Stig K. Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5602 - 5603