Fraxetin

Modify Date: 2025-08-20 22:04:55

Fraxetin structure	Common Name	Fraxetin
	CAS Number	574-84-5	Molecular Weight	208.167
	Density	1.5±0.1 g/cm3	Boiling Point	472.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈O₅	Melting Point	230-232°C
	MSDS	Chinese USA	Flash Point	196.0±22.2 °C
	Symbol	GHS07	Signal Word	Warning

Use of Fraxetin

Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis[1].

Name	7,8-dihydroxy-6-methoxychromen-2-one
Synonym	More Synonyms

Description	Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
References	[1]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104. [2]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378.

Description

Fraxetin is isolated from Cortex Fraxini. Fraxetin has antitumor, anti-oxidation effects and anti-inflammory effects. Fraxetin induces apoptosis[1].

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

References

[1]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104.

[2]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378.

Density	1.5±0.1 g/cm3
Boiling Point	472.0±45.0 °C at 760 mmHg
Melting Point	230-232°C
Molecular Formula	C₁₀H₈O₅
Molecular Weight	208.167
Flash Point	196.0±22.2 °C
Exact Mass	208.037170
PSA	79.90000
LogP	0.59
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.648
InChIKey	HAVWRBANWNTOJX-UHFFFAOYSA-N
SMILES	COc1cc2ccc(=O)oc2c(O)c1O
Storage condition	2~8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
HS Code	2932209090

Precursor 8
CAS#:73815-12-0 fraxetin diacetate CAS#:4055-69-0 2,3-dihydroxy-4... CAS#:71765-80-5 6-Methoxy-7-(3-... CAS#:77369-04-1 obtusicin
CAS#:667876-16-6 2,3-di[(isoprop... CAS#:2103-57-3 2,3,4-Trimethox... CAS#:24778-11-8 7-β-D-glucopyra... CAS#:89019-07-8 8-Acetyl-7-meth...
DownStream 6
CAS#:486-21-5 Isofraxidin CAS#:525-21-3 Fraxidin CAS#:28843-40-5 7,8-METHYLENEDI... CAS#:6035-49-0 6,7,8-Trimethox...
CAS#:114371-80-1 6,7,8-trihydrox... CAS#:84575-10-0 Cleomiscosin C

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

[Studies on chemical constituents from stem barks of Fraxinus paxiana].

Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008)

To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with...

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

Biochimie 95(10) , 1848-54, (2013)

Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihy...

[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].

Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008)

To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech...

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Induction of apoptosis in human U937 cells assessed as active 11 kDa fragment of casp...
Source: ChEMBL
Target: U-937
External Id: CHEMBL2209386

Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Source: ChEMBL
Target: U-937
External Id: CHEMBL2209398

Name: Antiproliferative activity against human U937 cells assessed as incorporation of [3H]...
Source: ChEMBL
Target: U-937
External Id: CHEMBL2209399

Name: Inhibition of clonogenic activity in human U937 cells assessed as reduction of colony...
Source: ChEMBL
Target: U-937
External Id: CHEMBL2209396

Name: Cell cycle arrest in human U937 cells assessed as accumulation at sub-G0/G1 phase at ...
Source: ChEMBL
Target: U-937
External Id: CHEMBL2209397

Total 148, Current Page 1 of 15

EINECS 209-376-2

6-methoxy-7,8-dihydroxycoumarin

7,8-Dihydroxy-6-methoxy-2H-chromen-2-one

2H-1-Benzopyran-2-one,7,8-dihydroxy-6-methoxy

7,8-Dihydroxy-6-methoxycoumarin

7,8-dihydroxy-6-methoxy-benzopyran-2-one

7,8-Dihydroxy-6-methoxy-2H-1-benzopyran-2-one

Fraxetin

MFCD00006873

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China
Product Name: Fraxetin
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Fraxetin

Use of Fraxetin

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Fraxetin Biological Activity

Chemical & Physical Properties

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Precursor & DownStream

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FraxetinBioassay

Synonyms

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