MCL0129 tetrahydrochloride
Modify Date: 2023-01-14 09:41:23
MCL0129 tetrahydrochloride structure
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Common Name | MCL0129 tetrahydrochloride | ||
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| CAS Number | 574001-66-4 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H51Cl4FN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MCL0129 tetrahydrochlorideMCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued |
| Name | 1-[(2S)-2-(4-Fluorophenyl)-2-(4-isopropyl-1-piperazinyl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine tetrahydrochloride |
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| Synonym | More Synonyms |
| Description | MCL0129 is a selective, potent melanocortin-4 receptor (MC4R) antagonist with Ki of 7.9 nM, without affinity for MC1 and MC3; attenuates the alpha-MSH-increased cAMP formation in COS-1 cells expressing the MC4, does not affect basal cAMP levels; exhibits anxiolytic- and antidepressant-like activities in various rodent models. Depression Discontinued |
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| References | References 1. Chaki S, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):818-26. 2. Shimazaki T, et al. Pharmacol Biochem Behav. 2005 Mar;80(3):395-400. View Related Products by Target Melanocortin Receptor Depression |
| Molecular Formula | C34H51Cl4FN4O |
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| Piperazine, 1-[(1S)-1-(4-fluorophenyl)-2-[4-[4-(2-methoxy-1-naphthalenyl)butyl]-1-piperazinyl]ethyl]-4-(1-methylethyl)-, hydrochloride (1:4) |
| 1-[(2S)-2-(4-Fluorophenyl)-2-(4-isopropyl-1-piperazinyl)ethyl]-4-[4-(2-methoxy-1-naphthyl)butyl]piperazine tetrahydrochloride |