Heptelidic acid
Modify Date: 2026-07-16 16:10:30
Heptelidic acid structure
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Common Name | Heptelidic acid | ||
|---|---|---|---|---|
| CAS Number | 57710-57-3 | Molecular Weight | 280.31600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H20O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Heptelidic acidHeptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | heptelidic acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3]. |
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| Related Catalog | |
| Target |
Caspase-3 |
| In Vitro | Heptelidic acid is a sesquiterpene antibiotic, found in the culture filtrate of three different strains of fungi isolated from soil samples. Heptelidic acid produces organisms, fermentation, isolation and characterization[1]. Heptelidic acid inhibits Etoposide-induced apoptosis in human leukemia U937 cells[2].Heptelidic acid inhibits caspase- 3 induction in U937 cells with an IC50 value of 40 μM after 8 h of Etoposide treatment[2]. Heptelidic acid (Koningic acid; KA), a natural product obtained from the Trichoderma fungus, can directly bind to the active site of human GAPDH. The expression of T. koningii KAr-GAPDH successfully rescued cell viability in human cells treated with Heptelidic acid. HEK293T cells expressing T. koningii KAr-GAPDH exhibited complete cell viability after treatment with 0-200 μM Heptelidic acid with the IC50=5 μM[3]. Cell Viability Assay[3] Cell Line: HEK293T cells expressing KAr-GAPDH or EV (top left) Concentration: 0.1, 1, 10, 100, 1000 μM Incubation Time: 24 hours Result: IC50=5 μM. |
| In Vivo | Heptelidic acid (Koningic acid; KA) is bioavailable and induces dynamic changes to glycolysis in vivo[3]. Animal Model: 6-week old female Foxn1nu mice bearing BT-474 tumor[3] Dosage: 1, 2.5, 5, and 10 mg/kg Administration: Daily intraperitoneal (IP) injections, 24 hours Result: 1 mg/kg was determined to be the maximum tolerated dose (MTD) based upon behavioral monitoring and adverse events at higher doses (hemolysis, hematuria, and anemia). |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C15H20O5 |
|---|---|
| Molecular Weight | 280.31600 |
| Exact Mass | 280.13100 |
| PSA | 76.13000 |
| LogP | 1.62160 |
| InChIKey | JESMSCGUTIEROV-OWPBNPRWSA-N |
| SMILES | CC(C)C1CCC2(CO2)C2C(=O)OCC(C(=O)O)=CC12 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary
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Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary
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Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393473
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393472
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393471
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393470
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393469
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Name: Inhibition of GAPDH in CpG-A-stimulated human plasmacytoid dendritic cells at 10 uM a...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5393468
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Name: Binding affinity to human recombinant his tagged GAPDH expressed in Escherichia coli ...
Source: ChEMBL
Target: Glyceraldehyde-3-phosphate dehydrogenase
External Id: CHEMBL5326524
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (+)-heptelidic acid |
| 1,5a,6,7,8,9a-hexahydro-6-(1-methyl-ethyl)-1-oxo-spiro<2-benzoxepin-9(3H),2'oxirane>-4-carboxylic acid (heptelidic acid) |
| koningic acid |
| 1,5a,6,7,8,9a-hexahydro-6-(1-methyl-ethyl)-1-oxo-spiro[2-benzoxepin-9(3H),2'oxirane]-4-carboxylic acid (heptelidic acid) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the Chinese name of 57710-57-3? |
| A: Chinese name of 57710-57-3 is 57710-57-3. |
| Q: What is the English name of heptelidic acid? |
| A: The English name of heptelidic acid is heptelidic acid. |
| Q: What is the molecular weight of heptelidic acid? |
| A: Molecular weight of heptelidic acid is 280.31600. |
| Q: What is the InChIKey of heptelidic acid? |
| A: InChIKey of heptelidic acid is JESMSCGUTIEROV-OWPBNPRWSA-N. |
| Q: What is the molecular formula of heptelidic acid? |
| A: Molecular formula of heptelidic acid is C15H20O5. |
| Q: What is the LogP of heptelidic acid? |
| A: LogP of heptelidic acid is 1.62160. |
| Q: What English synonyms does heptelidic acid have? |
| A: English synonyms of heptelidic acid: (+)-heptelidic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methyl-ethyl)-1-oxo-spiro-4-carboxylic acid (heptelidic acid), koningic acid, 1,5a,6,7,8,9a-hexahydro-6-(1-methyl-ethyl)-1-oxo-spiro[2-benzoxepin-9(3H),2'oxirane]-4-carboxylic acid (heptelidic acid). |
| Q: What is the polar surface area (PSA) of heptelidic acid? |
| A: Polar surface area (PSA) of heptelidic acid is 76.13000. |
| Q: What are the uses of heptelidic acid? |
| A: Main uses of heptelidic acid: Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3]. |
| Q: What is the CAS number of heptelidic acid? |
| A: CAS number of heptelidic acid is 57710-57-3. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |