Salsolidine

Modify Date: 2024-01-30 14:30:35

Use of Salsolidine

Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

Name	6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline
Synonym	More Synonyms

Description	Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Natural Products >> Alkaloid Research Areas >> Neurological Disease
Target	MAO A[1]
In Vitro	Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki, 6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3].
References	[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.

Hazard Codes	Xi
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

rac-salsolidine

6,7-DIMETHOXY-1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE

1,2,3,4-tetrahydro-6,7-dimethoxy-1-methylisoquinoline

1-methyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline

Salsolidine

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Price: $77/10mM*1mLinDMSO

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