Diloxanide furoate

Modify Date: 2024-01-02 14:02:26

Diloxanide furoate Structure
Diloxanide furoate structure
Common Name Diloxanide furoate
CAS Number 3736-81-0 Molecular Weight 328.14700
Density N/A Boiling Point N/A
Molecular Formula C14H11Cl2NO4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning
Purity Quantity Budget Inquiry

 Use of Diloxanide furoate


Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis, is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.

 Names

Name [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate
Synonym More Synonyms

 Diloxanide furoate Biological Activity

Description Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis, is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.
Related Catalog
References

[1]. Castro Hermida JA, et al. Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate. Parasitol Res. 2001 Jun;87(6):449-52.

[2]. Martínez-Castillo M, et al. Flavonoids as a Natural Treatment Against Entamoeba histolytica. Front Cell Infect Microbiol. 2018 Jun 22;8:209.

 Chemical & Physical Properties

Molecular Formula C14H11Cl2NO4
Molecular Weight 328.14700
Exact Mass 327.00700
PSA 59.75000
LogP 3.26530
Storage condition 2-8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LV1821800
CHEMICAL NAME :
2-Furoic acid, ester with 2,2-dichloro-4'-hydroxy-N-methylacetanilide
CAS REGISTRY NUMBER :
3736-81-0
LAST UPDATED :
198608
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H11-Cl2-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases 22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LV1821800

 Articles26

More Articles
Kinetic spectrophotometric H-point standard addition method for the simultaneous determination of diloxanide furoate and metronidazole in binary mixtures and biological fluids.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 592-8, (2013)

Simple, reliable, and sensitive kinetic spectrophotometric method has been developed for the simultaneous determination of diloxanide furoate and metronidazole using H-point standard addition method (...

Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation.

Pak. J. Pharm. Sci. 26(1) , 175-83, (2013)

This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr...

A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.

BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)

 Synonyms

Amebiazol
Miforon
MFCD00083302
Diclofurazol
Diloxanid furoate
Furamide (amebicide)
Entamide furoate
Furentomin
Entamide 2-furoate
Histomibal
DILOXANIDE FUROATE
EINECS 223-108-1
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