SU4312
Modify Date: 2024-01-16 18:33:06
SU4312 structure
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Common Name | SU4312 | ||
|---|---|---|---|---|
| CAS Number | 5812-07-7 | Molecular Weight | 264.32200 | |
| Density | 1.219g/cm3 | Boiling Point | 497.1ºC at 760 mmHg | |
| Molecular Formula | C17H16N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 254.5ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SU4312SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1]. |
| Name | SU 4312 |
|---|---|
| Synonym | More Synonyms |
| Description | SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively[1]. |
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| Related Catalog | |
| Target |
PDGFR Flk-1 |
| In Vitro | Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers[1]. |
| References |
| Density | 1.219g/cm3 |
|---|---|
| Boiling Point | 497.1ºC at 760 mmHg |
| Molecular Formula | C17H16N2O |
| Molecular Weight | 264.32200 |
| Flash Point | 254.5ºC |
| Exact Mass | 264.12600 |
| PSA | 32.34000 |
| LogP | 3.38330 |
| Index of Refraction | 1.683 |
| Storage condition | -20℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| RIDADR | NONH for all modes of transport |
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The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
Br. J. Pharmacol. 168(5) , 1201-14, (2013) SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative dis... |
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Automated image-based phenotypic analysis in zebrafish embryos.
Dev. Dyn. 238(3) , 656-63, (2009) Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical scre... |
| 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one |
| NSC 86429 |