3,3',5'-triiodothyronine

Modify Date: 2024-01-01 19:36:14

3,3',5'-triiodothyronine Structure
3,3',5'-triiodothyronine structure
Common Name 3,3',5'-triiodothyronine
CAS Number 5817-39-0 Molecular Weight 650.974
Density 2.4±0.1 g/cm3 Boiling Point 534.6±50.0 °C at 760 mmHg
Molecular Formula C15H12I3NO4 Melting Point 234-238ºC(lit.)
MSDS Chinese USA Flash Point 277.1±30.1 °C
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Use of 3,3',5'-triiodothyronine


Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].

 Names

Name 3,3',5'-triiodothyronine
Synonym More Synonyms

 3,3',5'-triiodothyronine Biological Activity

Description Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2].
Related Catalog
References

[1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9.

[2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749.

 Chemical & Physical Properties

Density 2.4±0.1 g/cm3
Boiling Point 534.6±50.0 °C at 760 mmHg
Melting Point 234-238ºC(lit.)
Molecular Formula C15H12I3NO4
Molecular Weight 650.974
Flash Point 277.1±30.1 °C
Exact Mass 650.790039
PSA 92.78000
LogP 5.39
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.763
Storage condition 2-8°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R36/37/38
Safety Phrases 36
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 3
RTECS AY6750000
HS Code 2922509090

 Synthetic Route

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3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: European Journal of Clinical Pharmacology, , vol. 55, # 11-12 p. 807 - 814

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3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069

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3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Journal of Medicinal Chemistry, , vol. 19, # 8 p. 1067 - 1069

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249

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3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9246 - 9249

~%

3,3',5'-triiodothyronine Structure

3,3',5'-triiodo...

CAS#:5817-39-0

Literature: Zeitschrift fuer Physikalische Chemie (Leipzig), , vol. 271, # 1 p. 223 - 226

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

(S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid
3,3',5'-Triiodo-L-thyronine
Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-
Reverse triiodothyronine
REVERSE T3
O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine
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