MX1013

Modify Date: 2024-01-10 08:02:07

MX1013 Structure
MX1013 structure
Common Name MX1013
CAS Number 582316-00-5 Molecular Weight 382.38300
Density 1.258g/cm3 Boiling Point 639.809ºC at 760 mmHg
Molecular Formula C18H23FN2O6 Melting Point N/A
MSDS N/A Flash Point 340.745ºC

 Use of MX1013


MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM[1].

 Names

Name 5-fluoro-3-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-4-oxopentanoic acid
Synonym More Synonyms

 MX1013 Biological Activity

Description MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM[1].
Related Catalog
Target

Caspase

In Vitro MX1013 inhibits caspases 1, 3, 6, 7, 8, and 9, with IC50 values ranging from 5 to 20 nm. MX1013 is selective for caspases, and is a poor inhibitor of noncaspase proteases, such as cathepsin B, calpain I, or Factor Xa (IC50 values >10 μm)[1]. MX1013 inhibits three key markers of apoptosis: the proteolytic maturation of caspase 3, the caspase-mediated cleavage of PARP, and the fragmentation of genomic DNA[1]. Cell Proliferation Assay[1] Cell Line: Jurkat T-lymphocytes Concentration: 0, 0.05, 0.1, 0.25, 0.5 μM Incubation Time: Preincubated for 2 h Result: Neither caspase 3 processing nor PARP cleavage could be detected at 0.5 μM. At concentrations of 0.05 μM, caspase 3 processing and PARP cleavage were still markedly reduced.
In Vivo MX1013 is an effective antiapoptotic agent in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1]. Animal Model: Female ND4 Swiss Webster mice (16.5-21 g)[1] Dosage: 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm Tris-HCl, pH 8.0) Administration: Injected i.v. Result: The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg dose protected 100% of the mice at the 3 h time point.
References

[1]. Wu Yang, et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br J Pharmacol. 2003 Sep;140(2):402-12.

 Chemical & Physical Properties

Density 1.258g/cm3
Boiling Point 639.809ºC at 760 mmHg
Molecular Formula C18H23FN2O6
Molecular Weight 382.38300
Flash Point 340.745ºC
Exact Mass 382.15400
PSA 121.80000
LogP 2.21730
Index of Refraction 1.523

 Safety Information

HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Z-Val-DL-Asp-fluoromethylketone
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: MX1013
  • Price: $500.0/100mg $900.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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Price: ¥10631.4/1g

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