Tilomisole

Modify Date: 2025-08-27 18:24:09

Tilomisole Structure
Tilomisole structure
Common Name Tilomisole
CAS Number 58433-11-7 Molecular Weight 342.79900
Density 1.51g/cm3 Boiling Point N/A
Molecular Formula C17H11ClN2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tilomisole


Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].

 Names

Name 2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
Synonym More Synonyms

 Tilomisole Biological Activity

Description Tilomisole (Wy 18251) is a benzimidazothiazole experimental drug with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].
Related Catalog
References

[1]. Dillman RO, et al. WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients. Mol Biother. 1992;4(1):10-14.

[2]. Darwish SA, et al. New tilomisole-based benzimidazothiazole derivatives as anti-inflammatory agents: Synthesis, in vivo, in vitro evaluation, and in silico studies [published online ahead of print, 2022 Jan 29]. Bioorg Chem. 2022;120:105644.

 Chemical & Physical Properties

Density 1.51g/cm3
Molecular Formula C17H11ClN2O2S
Molecular Weight 342.79900
Exact Mass 342.02300
PSA 82.84000
LogP 4.49650
Index of Refraction 1.746

 Synthetic Route

~91%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;

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Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: John Wyeth and Brother Ltd.; American Home Products Corporation Patent: US4812574 A1, 1989 ;

~%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: Bell; Wei Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530

~%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: Bell; Wei Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530

~%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: Bell; Wei Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530

~%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: Bell; Wei Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530

~%

Tilomisole Structure

Tilomisole

CAS#:58433-11-7

Literature: Bell; Wei Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 524 - 530

 Synonyms

Tilomisol
Tilomisol [Spanish]
Tilomisole (USAN/INN)
Tilomisolum
3 (4 chlorophenyl)thiazolo[3,2 a]benzimidazole 2 acetic acid
3-(p-chlorophenyl)-thiazolo[3,2-a]benzimidazole-2-acetic acid
Tilomisolum [Latin]
[3-(4-chloro-phenyl)-benzo[4,5]imidazo[2,1-b]thiazol-2-yl]-acetic acid
TILOMISOLE
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