Licochalcone B

Modify Date: 2024-01-04 12:44:21

Licochalcone B Structure
Licochalcone B structure
Common Name Licochalcone B
CAS Number 58749-23-8 Molecular Weight 286.279
Density 1.4±0.1 g/cm3 Boiling Point 550.5±50.0 °C at 760 mmHg
Molecular Formula C16H14O5 Melting Point 196-197ºC
MSDS N/A Flash Point 208.5±23.6 °C

 Use of Licochalcone B


Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].

 Names

Name (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Synonym More Synonyms

 Licochalcone B Biological Activity

Description Licochalcone B is an extract from the root of Glycyrrhiza inflate. Licochalcone B inhibits amyloid β (Aβ42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ions[1].
References

[1]. Cao Y, et al. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Nat Prod Res. 2018 Oct 22:1-4.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 550.5±50.0 °C at 760 mmHg
Melting Point 196-197ºC
Molecular Formula C16H14O5
Molecular Weight 286.279
Flash Point 208.5±23.6 °C
Exact Mass 286.084137
PSA 86.99000
LogP 2.57
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.684
Storage condition 2-8C

 Synthetic Route

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Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966

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Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Islam, Azizul; Khan, Saeed Ahmad; Krishnamurti, M. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 10 p. 965 - 966

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Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 21, # 10 p. 965 - 966

~%

Licochalcone B Structure

Licochalcone B

CAS#:58749-23-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 1 p. 181 - 185

 Synonyms

2-methoxy-3,4,4'-trihydroxychalcone
Licochalcone B
Licochalcon B
(2E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
licochalcone