| Description |
Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.
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| Related Catalog |
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| In Vivo |
Pamatolol is well absorbed in the gastro-intestinal tract and excreted in the urine of man, dogs, rats and mice after oral administration, mainly in unchanged form, within 24 hrs[1].
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| Animal Admin |
Three male Sprague-Dawley rats weighing 200-250 g are given pamatolol-sulphate dissolved in water at a dose of 50 mg/kg (10 μCi/mg) by means of a stomach tube. The rats are housed in metabolic cages that allows for separate collection of urine and feces for a 24 hr period. They are given a commercial pellet diet and drinking water ad libitum.
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| References |
[1]. Hoffmann KJ, et al. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73.
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