59110-35-9

59110-35-9 structure

Name: Pamatolol
Chemical Name: methyl N-[2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethyl]carbamate
CAS Number: 59110-35-9
Molecular Formula: C₁₆H₂₆N₂O₄
Molecular Weight: 310.38900
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-10 11:10:29
Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.

Name	methyl N-[2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]ethyl]carbamate
Synonyms	Pamatolol [INN] Pamatololum [INN-Latin] Pamatololum UNII-20G2S6V53L Pamatolol Methyl N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenethyl)carbamat

Description	Pamatolol is a cardioselective beta-adrenoceptor antagonist without sympathomimetic activity.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
In Vivo	Pamatolol is well absorbed in the gastro-intestinal tract and excreted in the urine of man, dogs, rats and mice after oral administration, mainly in unchanged form, within 24 hrs[1].
Animal Admin	Three male Sprague-Dawley rats weighing 200-250 g are given pamatolol-sulphate dissolved in water at a dose of 50 mg/kg (10 μCi/mg) by means of a stomach tube. The rats are housed in metabolic cages that allows for separate collection of urine and feces for a 24 hr period. They are given a commercial pellet diet and drinking water ad libitum.
References	[1]. Hoffmann KJ, et al. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73.