3'-bromo-5'-chloro-2'-hydroxyacetophenone

Modify Date: 2024-01-02 11:07:49

3'-bromo-5'-chloro-2'-hydroxyacetophenone Structure
3'-bromo-5'-chloro-2'-hydroxyacetophenone structure
Common Name 3'-bromo-5'-chloro-2'-hydroxyacetophenone
CAS Number 59443-15-1 Molecular Weight 249.48900
Density 1.691g/cm3 Boiling Point 297.8ºC at 760 mmHg
Molecular Formula C8H6BrClO2 Melting Point 100-103 °C(lit.)
MSDS Chinese USA Flash Point 133.9ºC
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 3'-bromo-5'-chloro-2'-hydroxyacetophenone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.691g/cm3
Boiling Point 297.8ºC at 760 mmHg
Melting Point 100-103 °C(lit.)
Molecular Formula C8H6BrClO2
Molecular Weight 249.48900
Flash Point 133.9ºC
Exact Mass 247.92400
PSA 37.30000
LogP 3.01070
Index of Refraction 1.604

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2914700090

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

 Articles4

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Bioorg. Med. Chem. 19(8) , 2659-65, (2011)

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Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.

J. Org. Chem. 74(7) , 2755-9, (2009)

A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner...

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.

J. Med. Chem. 55 , 7104-13, (2012)

A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disord...

 Synonyms

MFCD00857068
1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone
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