3'-bromo-5'-chloro-2'-hydroxyacetophenone
3'-bromo-5'-chloro-2'-hydroxyacetophenone structure
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Common Name | 3'-bromo-5'-chloro-2'-hydroxyacetophenone | ||
|---|---|---|---|---|
| CAS Number | 59443-15-1 | Molecular Weight | 249.48900 | |
| Density | 1.691g/cm3 | Boiling Point | 297.8ºC at 760 mmHg | |
| Molecular Formula | C8H6BrClO2 | Melting Point | 100-103 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 133.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.
Bioorg. Med. Chem. 19(8) , 2659-65, (2011) A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect on microtubule assembly. All compounds showed cytotoxic activity, ... |
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Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.
J. Org. Chem. 74(7) , 2755-9, (2009) A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner using microwave heating. Performing the reaction using dii... |
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Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.
J. Med. Chem. 55 , 7104-13, (2012) A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disorders. The analogues were efficiently synthesized in a one-st... |
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Proline-mediated formation of novel chroman-4-one tetrahydropyrimidines. Fridén-Saxin M, et al.
Tetrahedron 68(35) , 7035-7040, (2012)
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