Zearalanone
Modify Date: 2025-08-20 19:28:56
Zearalanone structure
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Common Name | Zearalanone | ||
|---|---|---|---|---|
| CAS Number | 5975-78-0 | Molecular Weight | 320.380 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 576.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H24O5 | Melting Point | 184-186ºC | |
| MSDS | Chinese USA | Flash Point | 209.2±23.6 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
Use of ZearalanoneZearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1]. |
| Name | (S)-Zearalanone |
|---|---|
| Synonym | More Synonyms |
| Description | Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1]. |
|---|---|
| Related Catalog | |
| Target |
Estrogen receptor |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.8±50.0 °C at 760 mmHg |
| Melting Point | 184-186ºC |
| Molecular Formula | C18H24O5 |
| Molecular Weight | 320.380 |
| Flash Point | 209.2±23.6 °C |
| Exact Mass | 320.162384 |
| PSA | 83.83000 |
| LogP | 3.45 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.526 |
| InChIKey | APJDQUGPCJRQRJ-LBPRGKRZSA-N |
| SMILES | CC1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1 |
| Storage condition | −20°C |
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H315-H319-H332-H335-H351 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22-36/37/38-40 |
| Safety Phrases | 22-26-36 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
| HS Code | 29322090 |
|
~19%
Zearalanone CAS#:5975-78-0 |
| Literature: El-Sharkawy, Saleh H.; Abul-Hajj, Yusuf J. Journal of Organic Chemistry, 1988 , vol. 53, # 3 p. 515 - 519 |
| Precursor 1 | |
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| DownStream 0 | |
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Preliminary estimation of deoxynivalenol excretion through a 24 h pilot study.
Toxins (Basel.) 7 , 705-18, (2015) A duplicate diet study was designed to explore the occurrence of 15 Fusarium mycotoxins in the 24 h-diet consumed by one volunteer as well as the levels of mycotoxins in his 24 h-collected urine. The ... |
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Development of a multi-toxin method for investigating the carryover of zearalenone, deoxynivalenol and their metabolites into milk of dairy cows.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32(3) , 371-80, (2015) A dose-response study was carried out to examine the carryover of zearalenone (ZEN), deoxynivalenol (DON) and their metabolites into bovine milk. Therefore, a feeding trial with 30 dairy cows fed with... |
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Development and validation of an UHPLC-MS/MS method for the determination of mycotoxins in grass silages.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 2101-12, (2015) An ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) multi-mycotoxin analytical method was developed to simultaneously identify and quantify 20 mycotoxins in grass si... |
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytotoxicity against in mouse 3T3-Y9/B12 cells at 10 uM
Source: ChEMBL
Target: N/A
External Id: CHEMBL968266
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet
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