OAC-2
Modify Date: 2026-07-01 13:13:42
OAC-2 structure
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Common Name | OAC-2 | ||
|---|---|---|---|---|
| CAS Number | 6019-39-2 | Molecular Weight | 236.269 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 364.3±15.0 °C at 760 mmHg | |
| Molecular Formula | C15H12N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 174.1±20.4 °C | |
Use of OAC-2OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. |
| Name | oac2 |
|---|---|
| Synonym | More Synonyms |
| Description | OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter. |
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| Related Catalog | |
| In Vitro | Octamer-binding transcription factor 4 (Oct4) is a master regulator of the induction and maintenance of cellular pluripotency, and has crucial roles in early stages of differentiation. It is the only factor that cannot be substituted by other members of the same protein family to induce pluripotency[1]. Oct4 has been shown to be an essential regulator of embryonic stem cell (ESC) pluripotency and key to the reprogramming process. OAC2 is a structural analog of OAC1. OAC2 activates both Oct4 and Nanog reporters to a similar extent as OAC1. OAC1 and its two structural analogs OAC2 and OAC3 enhances reprogramming efficiency fourfold, up to as high as 2.75%, and accelerates the appearance of iPSC colonies 3 to 4 d when used in combination with the four reprogramming factors, Oct4, Sox2, Klf4, and c-Myc[2]. |
| Cell Assay | The Oct4-luc or Nanog-luc cells are treated with compound OAC1 or its structural analogs OAC2, OAC3 at 1 μM concentration or at indicated concentrations. Other compounds used include 2 μM BIO, 2 μM BIX, 2 μM 5'-azacytidine, 25 μg/mL Vitamin C, 10 nM Am580, 5 μM tranylcypromine, and 0.5 mM valporic acid. Luciferase reporter assays are performed 24 h after compound treatment or at indicated time points. For Topflash reporter assays, 0.2 μg β-catenin–responsive Topflash reporter gene plasmid is introduced into CV1 cells using trasfection. Compounds are added 6 h after transfection. Luciferase activity is measured 48 h after compound treatment using the Glo Luciferase Assay System[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 364.3±15.0 °C at 760 mmHg |
| Molecular Formula | C15H12N2O |
| Molecular Weight | 236.269 |
| Flash Point | 174.1±20.4 °C |
| Exact Mass | 236.094955 |
| PSA | 44.89000 |
| LogP | 2.54 |
| Appearance of Characters | light yellow solid |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.743 |
| InChIKey | JCAFGYWSIWYMOX-UHFFFAOYSA-N |
| SMILES | O=C(Nc1ccc2[nH]ccc2c1)c1ccccc1 |
| Storage condition | -20℃ |
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OAC-2 CAS#:6019-39-2 |
| Literature: ASTEX TECHNOLOGY LIMITED Patent: WO2003/87087 A2, 2003 ; Location in patent: Page/Page column 39 ; WO 03/087087 A2 |
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~97%
OAC-2 CAS#:6019-39-2 |
| Literature: Macor; Blank; Fox; Lebel; Newman; Post; Ryan; Schmidt; Schulz; Koe Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2509 - 2512 |
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OAC-2 CAS#:6019-39-2 |
| Literature: Terent'ew et al. Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511 |
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~%
OAC-2 CAS#:6019-39-2 |
| Literature: Terent'ew et al. Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511 |
|
~%
OAC-2 CAS#:6019-39-2 |
| Literature: Terent'ew et al. Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511 |
|
~%
OAC-2 CAS#:6019-39-2 |
| Literature: Terent'ew et al. Zhurnal Obshchei Khimii, 1959 , vol. 29, p. 2541,2550; engl. Ausg. S. 2504, 2511 |
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
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Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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