Guanabenz
Guanabenz structure
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Common Name | Guanabenz | ||
|---|---|---|---|---|
| CAS Number | 60329-03-5 | Molecular Weight | 231.08200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H8Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Guanabenz(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Guanabenz |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
α2-adrenoceptor, GADD34[1][2] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C8H8Cl2N4 |
|---|---|
| Molecular Weight | 231.08200 |
| Exact Mass | 230.01300 |
| PSA | 76.76000 |
| LogP | 3.00130 |
| InChIKey | WDZVGELJXXEGPV-YIXHJXPBSA-N |
| SMILES | NC(N)=NN=Cc1c(Cl)cccc1Cl |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:83-38-5
CAS#:79-17-4This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactos...
Source: ChEMBL
Target: Neuropeptide FF receptor 1
External Id: CHEMBL1058559
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Name: Agonist activity at human NPFF2 receptor expressed in cells assessed as beta-galactos...
Source: ChEMBL
Target: Neuropeptide FF receptor 2
External Id: CHEMBL1058557
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Name: Anti-prion activity against [URE3] protein in Saccharomyces cerevisiae SB34 at 100 uM...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322425
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of Guanabenz? |
| A: Polar surface area (PSA) of Guanabenz is 76.76000. |
| Q: What is the LogP of Guanabenz? |
| A: LogP of Guanabenz is 3.00130. |
| Q: What are the downstream products of Guanabenz? |
| A: Related downstream products(CAS) of Guanabenz: 83-38-5;79-17-4. |
| Q: What is the CAS number of Guanabenz? |
| A: CAS number of Guanabenz is 60329-03-5. |
| Q: What is the molecular formula of Guanabenz? |
| A: Molecular formula of Guanabenz is C8H8Cl2N4. |
| Q: What is the InChIKey of Guanabenz? |
| A: InChIKey of Guanabenz is WDZVGELJXXEGPV-YIXHJXPBSA-N. |
| Q: What is the molecular weight of Guanabenz? |
| A: Molecular weight of Guanabenz is 231.08200. |
| Q: What is the SMILES notation of Guanabenz? |
| A: SMILES notation of Guanabenz is NC(N)=NN=Cc1c(Cl)cccc1Cl. |
| Q: What is the English name of Guanabenz? |
| A: The English name of Guanabenz is Guanabenz. |
| Q: What are the uses of Guanabenz? |
| A: Main uses of Guanabenz: (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2]. |