Guanabenz
Modify Date: 2025-08-27 18:49:22
Guanabenz structure
|
Common Name | Guanabenz | ||
|---|---|---|---|---|
| CAS Number | 60329-03-5 | Molecular Weight | 231.08200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C8H8Cl2N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Guanabenz(E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2]. |
| Name | Guanabenz |
|---|
| Description | (E)-Guanabenz ((E)-Wy-8678) is an orally active central α2-adrenoceptor agonist. (E)-Guanabenz has antihypertensive activity, acts via stimulating central α2-adrenoceptors, and reducing net sympathetic outflow into the periphery. (E)-Guanabenz also directly binds to and inhibits GADD34, and has neuroprotective activity. (E)-Guanabenz can be used for researching hypertension and Parkinson disease[1][2]. |
|---|---|
| Related Catalog | |
| Target |
α2-adrenoceptor, GADD34[1][2] |
| References |
| Molecular Formula | C8H8Cl2N4 |
|---|---|
| Molecular Weight | 231.08200 |
| Exact Mass | 230.01300 |
| PSA | 76.76000 |
| LogP | 3.00130 |
| InChIKey | WDZVGELJXXEGPV-YIXHJXPBSA-N |
| SMILES | NC(N)=NN=Cc1c(Cl)cccc1Cl |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:83-38-5
CAS#:79-17-4|
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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|
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
|
|
Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
|
|
Name: Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactos...
Source: ChEMBL
Target: Neuropeptide FF receptor 1
External Id: CHEMBL1058559
|
|
Name: Agonist activity at human NPFF2 receptor expressed in cells assessed as beta-galactos...
Source: ChEMBL
Target: Neuropeptide FF receptor 2
External Id: CHEMBL1058557
|
|
Name: Anti-prion activity against [URE3] protein in Saccharomyces cerevisiae SB34 at 100 uM...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322425
|
|
Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
|
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