Guanabenz

• 常用名: Guanabenz
• 英文名: Guanabenz
• CAS号: 60329-03-5
• 分子量: 231.08200
• 密度: N/A
• 沸点: N/A
• 分子式: C₈H₈Cl₂N₄
• 熔点: N/A
• 闪点: N/A

Guanabenz用途

(E) -Guanabenz((E)-Wy-8678)是一种口服活性中枢α2-肾上腺素受体激动剂。(E) -Guanabenz具有降压活性,通过刺激中枢α2-肾上腺素能受体发挥作用,并减少交感神经向外周的净流出。(E) -Guanabenz还直接结合并抑制GADD34,并具有神经保护活性。(E) -Guanabenz可用于研究高血压和帕金森病[1][2]。

Guanabenz名称

• 英文名: Guanabenz

Guanabenz生物活性

• 描述: (E) -Guanabenz((E)-Wy-8678)是一种口服活性中枢α2-肾上腺素受体激动剂。(E) -Guanabenz具有降压活性,通过刺激中枢α2-肾上腺素能受体发挥作用,并减少交感神经向外周的净流出。(E) -Guanabenz还直接结合并抑制GADD34,并具有神经保护活性。(E) -Guanabenz可用于研究高血压和帕金森病[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
  研究领域 >> 神经疾病
• 靶点实验:

  α2-adrenoceptor, GADD34[1][2]

• 参考文献:

  [1]. Sun X, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018 May;303:95-107.

  [2]. Xie J, et al. LC-MS/MS determination of guanabenz E/Z isomers and its application to in vitro and in vivo DMPK profiling studies. J Pharm Biomed Anal. 2021 Oct 25;205:114331.

Guanabenz物理化学性质

• 分子式: C₈H₈Cl₂N₄
• 分子量: 231.08200
• 精确质量: 230.01300
• PSA: 76.76000
• LogP: 3.00130
• InChIKey: WDZVGELJXXEGPV-YIXHJXPBSA-N
• SMILES: NC(N)=NN=Cc1c(Cl)cccc1Cl

Guanabenz靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Partition coefficient (logD6.8) 来源：ChEMBL 靶标：N/A External Id：CHEMBL646646

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Agonist activity at human NPFF1 receptor expressed in cells assessed as beta-galactos... 来源：ChEMBL 靶标：Neuropeptide FF receptor 1 External Id：CHEMBL1058559

实验名称：Agonist activity at human NPFF2 receptor expressed in cells assessed as beta-galactos... 来源：ChEMBL 靶标：Neuropeptide FF receptor 2 External Id：CHEMBL1058557

实验名称：Anti-prion activity against [URE3] protein in Saccharomyces cerevisiae SB34 at 100 uM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4322425

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

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