P1075

Modify Date: 2024-01-18 11:01:53

P1075 structure	Common Name	P1075
	CAS Number	60559-98-0	Molecular Weight	231.30
	Density	1.07g/cm3	Boiling Point	347.6ºC at 760 mmHg
	Molecular Formula	C₁₂H₁₇N₅	Melting Point	186-187 °C
	MSDS	N/A	Flash Point	164.1ºC

Use of P1075

P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].

Name	1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-ylguanidine
Synonym	More Synonyms

Description	P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation[1]. P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts[2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	EC50: 45 nM (SUR2-KIR6)[1].
References	[1]. Schwanstecher M, et al. Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J. 1998 Oct 1;17(19):5529-35. [2]. Oldenburg O, et al. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 2003 Sep;35(9):1035-42.

Density	1.07g/cm3
Boiling Point	347.6ºC at 760 mmHg
Melting Point	186-187 °C
Molecular Formula	C₁₂H₁₇N₅
Molecular Weight	231.30
Flash Point	164.1ºC
Exact Mass	231.14800
PSA	73.10000
LogP	2.57268
Index of Refraction	1.556

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF0175400

CHEMICAL NAME :: Guanidine, 2-cyano-1-tert-pentyl-3-(3-pyridyl)-

CAS REGISTRY NUMBER :: 60559-98-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H17-N5

MOLECULAR WEIGHT :: 231.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,773,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,773,1978

Hazard Codes	T+
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

p-1075

DC Chemicals Limited
China
Product Name: P-1075
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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P1075

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