Alafosfalin
Alafosfalin structure
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Common Name | Alafosfalin | ||
|---|---|---|---|---|
| CAS Number | 60668-24-8 | Molecular Weight | 196.14100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H13N2O4P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of AlafosfalinAlafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1]. |
| Name | (s)-alanyl-(r)-1-aminoethylphosphonic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1]. |
|---|---|
| Related Catalog | |
| Target |
Antibacterial[1] |
| In Vitro | Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1]. |
| In Vivo | After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t1/2) of approximately 20 minutes[2]. Animal Model: Pairs of male SpragueDawley rats (250 to 350 g)[2] Dosage: 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) Administration: Administrated by s.c. Result: Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |
| References |
| Molecular Formula | C5H13N2O4P |
|---|---|
| Molecular Weight | 196.14100 |
| Exact Mass | 196.06100 |
| PSA | 125.45000 |
| LogP | 0.76750 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:60687-36-7| HS Code | 2931900090 |
|---|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
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In vitro potentiation of cephalosporins by alafosfalin against urinary tract bacteria.
Antimicrob. Agents Chemother. 21(5) , 706-10, (1982) Potentiating activity of alafosfalin was examined in detail with 8 cephalosporins and mecillinam against 164 urinary bacteria representing 8 genera. Alafosfalin was generally comparable in activity to... |
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Alafosfalin as a selective agent for isolation of salmonella from clinical samples.
J. Clin. Microbiol. 40(11) , 3913-6, (2002) The selectivity of a range of culture media for the detection of Salmonella was assessed using 435 strains of gram-negative bacteria. These media showed limited ability to inhibit non-Salmonella strai... |
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Synergistic antibacterial activity between L-norvalyl-L-1-aminoethylphosphonic acid and nocardicin A.
Antimicrob. Agents Chemother. 25(5) , 607-11, (1984) The phosphonopeptide L- norvalyl -L-1- aminoethylphosphonic acid [ Nva -Ala(P)] has been studied in combination with 12 beta-lactam antibiotics for activity against Pseudomonas aeruginosa. Nocardicin ... |
| (1R)-1-(L-alanylamino)-ethylphosphonic acid |
| ALAFOSFALIN |
| H-L-Ala-L-AlaP(OH)2 |
| N-(S)-alanyl-(R)-1-aminoethanephosphonic acid |
| ALAPHOSPHIN |
| L-alanyl-L-1-aminoethylphosphonic acid |
| 1R-1-(L-alanylamino)-ethanephosphonic acid |
| L-ALANYL-L-ALA(P)-OH |
| (S)-Alanyl-(R)-1-aminoethylphosphonic acid,Alafosfalin,Alaphosphin |
| ((L)-(1-((N-L-alanyl)amino)ethyl))phosphonic acid |
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