Myristicin

Modify Date: 2024-01-03 04:01:30

Myristicin Structure
Myristicin structure
 Common Name Myristicin
CAS Number 607-91-0 Molecular Weight 192.211
Density 1.1±0.1 g/cm3 Boiling Point 276.5±0.0 °C at 760 mmHg
Molecular Formula C11H12O3 Melting Point <-20ºC
MSDS Chinese USA Flash Point 89.8±16.0 °C
Symbol GHS08
GHS08		 Signal Word Warning

 Use of Myristicin


Myristicine  act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others[1].

 Names

Name 4-methoxy-6-prop-2-enyl-1,3-benzodioxole
Synonym More Synonyms

 Myristicin Biological Activity

Description Myristicine  act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine abuse produce hallucinogenic effects, organ damage, deliriumand others[1].
Related Catalog
References

[1]. Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4.

[2]. Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31(1):119-123. Epub 2012 Aug 15.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 276.5±0.0 °C at 760 mmHg
Melting Point <-20ºC
Molecular Formula C11H12O3
Molecular Weight 192.211
Flash Point 89.8±16.0 °C
Exact Mass 192.078644
PSA 27.69000
LogP 3.26
Appearance of Characters oil | clear, light yellow
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.540

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY2625000
CHEMICAL NAME :
Benzene, 5-allyl-1-methoxy-2,3-(methylenedioxy)-
CAS REGISTRY NUMBER :
607-91-0
BEILSTEIN REFERENCE NO. :
0166218
LAST UPDATED :
199709
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H12-O3
MOLECULAR WEIGHT :
192.23
WISWESSER LINE NOTATION :
T56 BO DO CHJ FO1 H2U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
5700 ug/kg
TOXIC EFFECTS :
Behavioral - wakefulness Behavioral - euphoria Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4260 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Liver - fatty liver degeneration
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Liver - other changes Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H361f-H412
Precautionary Statements P201-P273-P308 + P313
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn
Risk Phrases R52/53
Safety Phrases S61
RIDADR UN 3082 9/PG 3
WGK Germany 1
RTECS CY2625000
Hazard Class 9.0
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles35

More Articles
Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.

Chem. Biol. Interact. 218 , 1-9, (2014)

Myristicin, an allylbenzene, is a major active component of various spices, such as nutmeg and cinnamon, plants from the Umbelliferae family or in some essential oils, such as oils of clove or marjora...

Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects.

J. Toxicol. Environ. Health. B. Crit. Rev. 15(6) , 365-95, (2012)

The methylenedioxyphenyl (MDP) substituent is a structural feature present in many plant chemicals that deter foraging by predatory insects and herbivores. With increasing use of herbal extracts in al...

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.

Nat. Prod. Commun. 8(9) , 1305-8, (2013)

We have hydrodistilled the essential oil (EO) from the aerial parts of the Bhutanese medicinal plant, Pleurospermum amabile using a Clevenger apparatus and evaluated this EO by GC/GC-MS and NMR analys...

 Synonyms

myristicine
4-methoxy-6-prop-2-en-1-yl-1,3-benzodioxole
6-Allyl-4-methoxy-1,3-benzodioxole
1,3-Benzodioxole, 4-methoxy-6-(2-propen-1-yl)-
MFCD00133549
Myristicin
4-Méthoxy-6-(2-propèn-1-yl)-1,3-benzodioxole
3-methoxy-4,5-methylenedioxyallylbenzene
1-allyl-4,5-methylenedioxy-3-methoxybenzene
EINECS 210-146-9
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Chemsrc provides Myristicin(CAS#:607-91-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Myristicin are included as well.>> amp version: Myristicin

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