Eugenol

Modify Date: 2026-07-23 16:32:52

Eugenol structure	Common Name	Eugenol
	CAS Number	97-53-0	Molecular Weight	164.201
	Density	1.1±0.1 g/cm3	Boiling Point	255.0±0.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂O₂	Melting Point	−12-−10 °C(lit.)
	MSDS	Chinese USA	Flash Point	119.8±8.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Eugenol

Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	eugenol
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Eugenol is an essential oil found in cloves with antibacterial, anthelmintic and antioxidant activity. Eugenol is shown to inhibit lipid peroxidation.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Parasite Natural Products >> Phenols Research Areas >> Inflammation/Immunology Research Areas >> Infection
Target	Bacterial, Parasite[1]
In Vitro	The essential oil of O. gratissimum, as well as eugenol, are efficient in inhibiting eclodibility of H. contortus eggs, showing possible utilizations in the treatment of gastrointestinal helmintosis of small ruminants. At 0.50% concentration, the essential oil and eugenol show a maximum eclodibility inhibition[1]. Eugenol inhibits superoxide anion generation in xanthine-xanthine oxidase system to an extent of 50% at concentrations of 250 μM. Eugenol also inhibits the generation of hydroxyl radicals to an extent of 70%. The OH-radical formation measured by the hydroxylation of salicylate to 2, 3-dihydroxy benzoate is inhibited to an extent of 46% by eugenol at 250 μM[2]. Eugenol protects against RS-induced development of IBS-like gastrointestinal dysfunction through modulation of HPA-axis and brain monoaminergic pathways apart from its antioxidant effect. Eugenol (50 mg/kg) reduces 80% of RS-induced increase in fecal pellets similar to that of ondansetron. Eugenol attenuates 80% of stress-induced increase in plasma corticosterone and modulates the serotonergic system in the PFC and amygdala. Eugenol attenuates stress-induced changes in norepinephrine and potentiates the antioxidant defense system in all brain regions[3].
In Vivo	Eugenol (33 mg/kg) administered orally for 2 days causes significant suppression of knee joint edema, which continues to be significantly reduced at the end of the treatment. After 2 days, eugenol-treated mycobacterial arthritic rats show a marked reduction in paw swelling[4].
Cell Assay	The essential oil and eugenol are diluted in aqueous solution of Tween 20 (0.5%) in the following concentrations: 0.0625, 0.12, 0.25, 0.5 and 1.0% to be used in the egg hatch test[1].
Animal Admin	Rats: The treatment groups of arthritic rats are given either ingwerol (0.33 mL/kg or 33 mg/kg) or eugenol (0.33 mL/kg or 33 mg/kg) orally 1 day prior to the induction of arthritis. This treatment is continued for 26 days on a daily basis. Mycobaterium trated rats receive physiological saline orally[4].
References	[1]. Pessoa LM, et al. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. and eugenol against Haemonchus contortus. Vet Parasitol. 2002 Oct 16;109(1-2):59-63. [2]. Reddy AC, et al. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygenspecies and the oxidation of ferrous iron. Mol Cell Biochem. 1994 Aug 17;137(1):1-8. [3]. Garabadu D, et al. Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome. Pharm Biol. 2015 Jul;53(7):968-74. [4]. Sharma JN, et al. Suppressive effects of eugenol and ginger oil on arthritic rats. Pharmacology. 1994 Nov;49(5):314-8.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	255.0±0.0 °C at 760 mmHg
Melting Point	−12-−10 °C(lit.)
Molecular Formula	C₁₀H₁₂O₂
Molecular Weight	164.201
Flash Point	119.8±8.1 °C
Exact Mass	164.083725
PSA	29.46000
LogP	2.20
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.536
InChIKey	RRAFCDWBNXTKKO-UHFFFAOYSA-N
SMILES	C=CCc1ccc(O)c(OC)c1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents.
Water Solubility	slightly soluble

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Eugenol MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ4375000

CHEMICAL NAME :: Phenol, 4-allyl-2-methoxy-

CAS REGISTRY NUMBER :: 97-53-0

BEILSTEIN REFERENCE NO. :: 1366759

LAST UPDATED :: 199701

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C10-H12-O2

MOLECULAR WEIGHT :: 164.22

WISWESSER LINE NOTATION :: 1U2R DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human - man

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - pig

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1930 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - coma Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2580 mg/m3/4H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - chronic pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2130 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intratracheal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - chronic pulmonary edema

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 68 gm/kg/34D-I

TOXIC EFFECTS :: Liver - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 gm/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 gm/kg/14D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37080 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 300 ppb

REFERENCE :: SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949- Volume(issue)/page/year: 74,1365,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 36,75,1985 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,545,1975 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82100 No. of Facilities: 1034 (estimated) No. of Industries: 17 No. of Occupations: 31 No. of Employees: 37569 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82100 No. of Facilities: 9995 (estimated) No. of Industries: 82 No. of Occupations: 91 No. of Employees: 187937 (estimated) No. of Female Employees: 83766 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317-H319
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	SJ4375000
HS Code	29095090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:4125-45-5 2-methoxy-1-pro... CAS#:81391-19-7 1-[(4-hydroxy-3... CAS#:4125-43-3 2-Allyloxyanisole CAS#:76513-64-9 (2-((4-allyl-2-...
CAS#:93-28-7 Acetyleugenol CAS#:90-05-1 Guaiacol CAS#:107-05-1 ALLYL CHLORIDE CAS#:144150-79-8 2-methoxy-4-pro...
CAS#:6331-61-9 Eugenolglycolic acid
DownStream 10
CAS#:110057-59-5 2-(hydroxymethy... CAS#:115003-43-5 2-[(2-hydroxy-3... CAS#:487-11-6 Elemicin CAS#:5447-38-1 4-Acetoxy-3-met...
CAS#:607-91-0 Myristicin CAS#:144150-79-8 2-methoxy-4-pro... CAS#:1446-24-8 3-Allylphenol CAS#:14574-06-2 3-(4-hydroxy-3-...
CAS#:458-36-6 coniferyl aldehyde CAS#:458-35-5 Coniferyl alcohol

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909500000
Summary	2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Can Ocimum basilicum L. and Ocimum tenuiflorum L. in vitro culture be a potential source of secondary metabolites?

Food Chem. 194 , 55-60, (2015)

In this study Ocimum basilicum L. (OB) and Ocimum tenuiflorum L. (OT) in vitro culture standardisation for increasing eugenol distribution, in comparison to their respective field grown parts was carr...

Volatile Compounds from Grape Skin, Juice and Wine from Five Interspecific Hybrid Grape Cultivars Grown in Québec (Canada) for Wine Production.

Molecules 20 , 10980-1016, (2015)

Developed from crosses between Vitis vinifera and North American Vitis species, interspecific hybrid grape varieties are becoming economically significant in northern areas, where they are now extensi...

Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay.

Bioorg. Med. Chem. Lett. 20 , 2111-4, (2010)

The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity. Among them, eugen...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Growth inhibition of human HeLa cells at 10 uM to 1 mM after 24 hrs by MTT assay rela...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL4407030

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Antiproliferative activity against human HeLa cells at 150 uM after 24 hrs by MTT ass...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL4407032

Name: Antiproliferative activity against human HeLa cells after 24 hrs by MTT assay relativ...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL4407034

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Cytotoxicity against human PC3 cells at 41 ug/ml after 72 hrs in presence of 0.5 uM 2...
Source: ChEMBL
Target: PC-3
External Id: CHEMBL4407036

Name: Inhibition of 15-lipoxygenase form soybean
Source: ChEMBL
Target: N/A
External Id: CHEMBL1019440

Name: Mouse TRPA1 (Transient Receptor Potential channels)
Source: IUPHAR-DB
Target: TRPA1 (Transient Receptor Potential channels) [Mus musculus]
External Id: 485_Mouse

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: Antileishmanial activity against intracellular Leishmania infantum chagasi MHOM/BR/00...
Source: ChEMBL
Target: Leishmania infantum
External Id: CHEMBL3381331

Total 731, Current Page 1 of 74

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-Allyl-2-methoxyphenol

Eugenic acid

p-Allylguaiacol

2-methoxy-4-allyl phenol

2-methoxy-4-(prop-2-en-1-yl)phenol

Eugenol

2U1R DQ CO1

4-allylguaiacol

2-methoxy-4-(2-propen-1-yl)phenol

p-Eugenol

femano.2467

EINECS 202-589-1

1-allyl-4-hydroxy-3-methoxybenzene

2-Methoxy-4-allylphenol

Engenol

FA 100

Caryophyllic acid

FEMA 2467

MFCD00008654

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the molecular weight of eugenol?

A: Molecular weight of eugenol is 164.201.

Q: What is the polar surface area (PSA) of eugenol?

A: Polar surface area (PSA) of eugenol is 29.46000.

Q: What is the InChIKey of eugenol?

A: InChIKey of eugenol is RRAFCDWBNXTKKO-UHFFFAOYSA-N.

Q: What are the upstream materials of eugenol?

A: Related upstream materials(CAS) of eugenol: 4125-45-5;81391-19-7;4125-43-3;76513-64-9;93-28-7;90-05-1;107-05-1;144150-79-8;6331-61-9.

Q: What is the safety information for eugenol?

A: Safety information for eugenol: S26-S36-S24/25.

Q: What is the boiling point of eugenol?

A: Boiling point of eugenol is 255.0±0.0 °C at 760 mmHg.

Q: What is the CAS number of eugenol?

A: CAS number of eugenol is 97-53-0.

Q: What is the SMILES notation of eugenol?

A: SMILES notation of eugenol is C=CCc1ccc(O)c(OC)c1.

Q: What English synonyms does eugenol have?

A: English synonyms of eugenol: 4-Allyl-2-methoxyphenol, Eugenic acid, p-Allylguaiacol, 2-methoxy-4-allyl phenol, 2-methoxy-4-(prop-2-en-1-yl)phenol, Eugenol, 2U1R DQ CO1, 4-allylguaiacol, 2-methoxy-4-(2-propen-1-yl)phenol, p-Eugenol, femano.2467, EINECS 202-589-1, 1-allyl-4-hydroxy-3-methoxybenzene, 2-Methoxy-4-allylphenol, Engenol, FA 100, Caryophyllic acid, FEMA 2467, MFCD00008654.

Q: What is the LogP of eugenol?

A: LogP of eugenol is 2.20.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

BioBioPha

Dayang Chem (Hangzhou) Co., Ltd.

naturewill

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Eugenol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Eugenol
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Eugenol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: Eugenol
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Engenol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Eugenol
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

Eugenol suppliers

Price: $66/10mM*1mLinDMSO

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Eugenol

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