Meticillin

Modify Date: 2024-01-15 20:04:58

Meticillin Structure
Meticillin structure
Common Name Meticillin
CAS Number 61-32-5 Molecular Weight 380.41600
Density N/A Boiling Point N/A
Molecular Formula C17H20N2O6S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of Meticillin


Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

 Names

Name methicillin
Synonym More Synonyms

 Meticillin Biological Activity

Description Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].
Related Catalog
In Vitro Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].
In Vivo Methicillin (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].
References

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

 Chemical & Physical Properties

Molecular Formula C17H20N2O6S
Molecular Weight 380.41600
Exact Mass 380.10400
PSA 130.47000
LogP 1.27790

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
RIDADR NONH for all modes of transport
RTECS XH8930000

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles91

More Articles
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Bacteriophage as effective decolonising agent for elimination of MRSA from anterior nares of BALB/c mice.

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Preparation and in vitro-in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis.

Eur. J. Pharm. Sci. 63 , 204-15, (2014)

The objective of this study was to explore the potential of the nanostructured lipid carriers (NLCs) modified with chitosan oligosaccharide lactate (COL) for topical ocular application. Ofloxacin (OFX...

 Synonyms

Meticillin
meticillin
6β-(2,6-dimethoxy-benzoylamino)-penicillanic acid
METICILLIN
6-(2,6-dimethoxybenzamido)penicillinic acid
(2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Methicillin
methycillin
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