Tenuazonic acid-(Copper salt)

Modify Date: 2024-01-04 12:44:39

Tenuazonic acid-(Copper salt) structure	Common Name	Tenuazonic acid-(Copper salt)
	CAS Number	610-88-8	Molecular Weight	197.231
	Density	1.2±0.1 g/cm3	Boiling Point	401.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₅NO₃	Melting Point	74.5°C
	MSDS	Chinese USA	Flash Point	196.4±28.7 °C
	Symbol	GHS06	Signal Word	Danger

Use of Tenuazonic acid-(Copper salt)

Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor[2].

Name	Tenuazonic Acid
Synonym	More Synonyms

Description	Tenuazonic acid, belonging to tetramic acids that are the largest family of natural products, is a putative nonhost-selective mycotoxin isolated from Alternaria alternate[1]. Tenuazonic acid blocks electron transport beyond primary quinone acceptor (QA) by interacting with D1 protein and it is a broad-spectrum and effective photosystem II (PSII) inhibitor[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	PSII[2]
References	[1]. Zhou B, et al. An evaluation of tenuazonic acid, a potential biobased herbicide in cotton. Pest Manag Sci. 2019 Mar 7. [2]. Chen S, et al. Recent advances in tenuazonic acid as a potential herbicide. Pestic Biochem Physiol. 2017 Nov;143:252-257.

Density	1.2±0.1 g/cm3
Boiling Point	401.1±45.0 °C at 760 mmHg
Melting Point	74.5°C
Molecular Formula	C₁₀H₁₅NO₃
Molecular Weight	197.231
Flash Point	196.4±28.7 °C
Exact Mass	197.105194
PSA	66.40000
LogP	0.81
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.519
Storage condition	-20°C

Tenuazonic acid-(Copper salt) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7425000

CHEMICAL NAME :: 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

CAS REGISTRY NUMBER :: 610-88-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H15-N-O3

MOLECULAR WEIGHT :: 197.26

WISWESSER LINE NOTATION :: T5MV EHJ CV1 DQ EY2&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 81 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,87,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,65,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Hazard Codes	Xn
Risk Phrases	22
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	UY7425000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

ethyl L-isoleucinate

CAS#:921-74-4

Tenuazonic acid...

CAS#:610-88-8

Literature: Matsuo; Kitaguchi; Takata; Tanaka Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 8 p. 2494 - 2502

H-Ile-OMe.HCl

CAS#:18598-74-8

Tenuazonic acid...

CAS#:610-88-8

Literature: Poncet, Joel; Jouin, Patrick; Castro, Bertrand; Nicolas, Louisette; Boutar, Mohamed; Gaudemer, Alain Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 611 - 616

(2S,3S)-N-aceto...

CAS#:62972-98-9

Tenuazonic acid...

CAS#:610-88-8

N/A

CAS#:36576-19-9

Precursor 3
CAS#:921-74-4 ethyl L-isoleucinate CAS#:18598-74-8 H-Ile-OMe.HCl CAS#:62972-98-9 (2S,3S)-N-aceto...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Natural occurrence of four Alternaria mycotoxins in tomato- and citrus-based foods in China.

J. Agric. Food Chem. 63(1) , 343-8, (2015)

A total of 70 tomato-based and 86 citrus-based products collected in China were analyzed for alternariol, alternariol monomethyl ether, tentoxin, and tenuazonic acid by ultraperformance liquid chromat...

Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections.

Antimicrob. Agents Chemother. 53 , 4028-31, (2009)

The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of ...

Effects of nisin and reutericyclin on resistance of endospores of Clostridium spp. to heat and high pressure.

Food Microbiol. 34(1) , 46-51, (2013)

The effects of high pressure, temperature, and antimicrobial compounds on endospores of Clostridium spp. were examined. Minimal inhibitory concentrations (MIC) of nisin and reutericyclin were determin...

3-acetyl-5-(butan-2-yl)-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one

3-Acetyl-5-sec-butyl-4-hydroxy-1,5-dihydro-2H-pyrrol-2-one

4-acetyl-2-butan-2-yl-3-hydroxy-1,2-dihydropyrrol-5-one

2H-Pyrrol-2-one, 3-acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-