8-Bromo-2-methylquinoline

Modify Date: 2024-01-10 18:48:06

8-Bromo-2-methylquinoline Structure
8-Bromo-2-methylquinoline structure
Common Name 8-Bromo-2-methylquinoline
CAS Number 61047-43-6 Molecular Weight 222.081
Density 1.5±0.1 g/cm3 Boiling Point 299.7±20.0 °C at 760 mmHg
Molecular Formula C10H8BrN Melting Point 63-65ºC
MSDS N/A Flash Point 135.0±21.8 °C

 Names

Name 8-Bromo-2-methylquinoline
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 299.7±20.0 °C at 760 mmHg
Melting Point 63-65ºC
Molecular Formula C10H8BrN
Molecular Weight 222.081
Flash Point 135.0±21.8 °C
Exact Mass 220.984009
PSA 12.89000
LogP 2.97
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.654

 MSDS


Section I.Chemical Product and Company Identification
Chemical Name 8-Bromo-2-methylquinoline
Portland OR
SynonymQuinoline, 8-bromo-2-methyl- (CA INDEX NAME);
8-Bromoquinaldine
Chemical FormulaC10H8BrN
CAS Number61047-43-6

Section II.Composition and Information on Ingredients
Toxicology Data
Chemical NameCAS Number Percent (%)TLV/PEL
Min. 98.0 (GC, Not available.Not available.
8-Bromo-2-methylquinoline61047-43-6
T)

Section III. Hazards Identification
Acute Health EffectsIrritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the
eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.

Section V.Fire and Explosion Data
Not available.
May be combustible at high temperature.Auto-Ignition
Flammability
Flash PointsFlammable LimitsNot available.
Not available.
These products are toxic carbon oxides (CO, CO2), nitrogen oxides (NOx), halogenated compounds.
Combustion Products
Fire HazardsNot available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
8-Bromo-2-methylquinoline

Section VI.Accidental Release Measures
Spill CleanupIrritating material.
Use a shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for
Instructions
assistance on disposal.

Section VII. Handling and Storage
Handling and StorageIRRITANT. Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a
dry, cool place. Avoid excessive heat and light. Do not breathe dust.
Information

Section VIII. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
Engineering Controls
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Physical state @ 20°CSolid. (Crystal, powder. White, slightlySolubility
Not available.
pale yellow.)
Not available.
Specific Gravity
Molecular Weight222.08Partition CoefficientNot available.
Boiling Point132°C (269.6°F) @ 0.1 mmHgVapor PressureNot applicable.
Melting Point68°C (154.4°F)Vapor DensityNot available.
Not available.Not available.
Refractive IndexVolatility
Critical TemperatureNot available.OdorNot available.
Not available.Not available.
ViscosityTaste

Section X.Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of InstabilityAvoid excessive heat and light.
IncompatibilitiesNot available.

Section XI. Toxicological Information
RTECS NumberNot available.
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Not available.
Toxicity Data
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Inflammation of the eye
Acute Toxic Effects
is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or,
occasionally, blistering.
Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.

Section XII.Ecological Information
EcotoxicityNot available.
Not available.
Environmental Fate
Continued on Next Page
8-Bromo-2-methylquinoline

Section XIII. Disposal Considerations
Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
Not a DOT controlled material (United States).
DOT Classification
PIN NumberNot applicable.
Proper Shipping NameNot applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationNot available.
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsR36/37/38- Irritating to eyes, respiratory system and skin.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
HS Code 2933499090

 Synthetic Route

~52%

8-Bromo-2-methylquinoline Structure

8-Bromo-2-methy...

CAS#:61047-43-6

Literature: SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; CASAUBON, Rebecca, L. Patent: WO2010/101949 A1, 2010 ; Location in patent: Page/Page column 116; 117 ; WO 2010/101949 A1

~45%

8-Bromo-2-methylquinoline Structure

8-Bromo-2-methy...

CAS#:61047-43-6

Literature: Journal of Medicinal Chemistry, , vol. 52, # 3 p. 868 - 877

~%

8-Bromo-2-methylquinoline Structure

8-Bromo-2-methy...

CAS#:61047-43-6

Literature: US2007/274922 A1, ;

~%

8-Bromo-2-methylquinoline Structure

8-Bromo-2-methy...

CAS#:61047-43-6

Literature: Lord, Anna-Marie; Mahon, Mary F.; Lloyd, Matthew D.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2009 , vol. 52, # 3 p. 868 - 877

 Customs

HS Code 2933499090
Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

8-Bromo-2-methylquinoline
Quinoline, 8-bromo-2-methyl-