6-Chlorobenzo[D]Isoxazol-3-Ol

Modify Date: 2024-01-10 19:49:03

6-Chlorobenzo[D]Isoxazol-3-Ol Structure
6-Chlorobenzo[D]Isoxazol-3-Ol structure
Common Name 6-Chlorobenzo[D]Isoxazol-3-Ol
CAS Number 61977-29-5 Molecular Weight 169.565
Density 1.5±0.1 g/cm3 Boiling Point 336.7±22.0 °C at 760 mmHg
Molecular Formula C7H4ClNO2 Melting Point 218-220ºC
MSDS Chinese USA Flash Point 157.4±22.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 6-Chlorobenzo[D]Isoxazol-3-Ol


CBIO is a potent, cell-permeable, D-amino acid oxidase (DAO) reversible inhibitor. In rat models, CBIO prevents formalin-induced tonic pain but not acute nociception.

 Names

Name 6-Chlorobenzo[d]isoxazol-3-ol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 336.7±22.0 °C at 760 mmHg
Melting Point 218-220ºC
Molecular Formula C7H4ClNO2
Molecular Weight 169.565
Flash Point 157.4±22.3 °C
Exact Mass 168.993057
PSA 46.26000
LogP 1.49
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.674

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36/37/39
RIDADR NONH for all modes of transport
HS Code 2934999090

 Synthetic Route

~88%

6-Chlorobenzo[D]Isoxazol-3-Ol Structure

6-Chlorobenzo[D...

CAS#:61977-29-5

Literature: Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry Patent: EP2322520 A1, 2011 ; Location in patent: Page/Page column 12 ;

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6-Chlorobenzo[D]Isoxazol-3-Ol Structure

6-Chlorobenzo[D...

CAS#:61977-29-5

Literature: US5484763 A1, ;

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6-Chlorobenzo[D]Isoxazol-3-Ol Structure

6-Chlorobenzo[D...

CAS#:61977-29-5

Literature: EP2322520 A1, ;

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6-Chlorobenzo[D]Isoxazol-3-Ol Structure

6-Chlorobenzo[D...

CAS#:61977-29-5

Literature: EP2322520 A1, ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles2

More Articles
Salmonella evades D-amino acid oxidase to promote infection in neutrophils.

MBio 5(6) , e01886, (2014)

Neutrophils engulf and kill bacteria using oxidative and nonoxidative mechanisms. Despite robust antimicrobial activity, neutrophils are impaired in directing Salmonella clearance and harbor viable in...

Contributions of spinal D-amino acid oxidase to chronic morphine-induced hyperalgesia.

J. Pharm. Biomed. Anal. 116 , 131-8, (2015)

Spinal D-amino acid oxidase (DAAO) is an FAD-dependent peroxisomal flavoenzyme which mediates the conversion of neutral and polar D-amino acids (including D-serine) to the corresponding α-keto acids, ...

 Synonyms

6-Chloro-1,2-benzoxazol-3(2H)-one
1,2-Benzisoxazol-3(2H)-one, 6-chloro-
6-chloro-1,2-benzoxazol-3-one
6-Chlorobenzo[D]Isoxazol-3-Ol