Dopamine hydrochloride

Modify Date: 2024-01-02 16:44:36

Dopamine hydrochloride Structure
Dopamine hydrochloride structure
 Common Name Dopamine hydrochloride
CAS Number 62-31-7 Molecular Weight 189.639
Density N/A Boiling Point 337.7ºC at 760 mmHg
Molecular Formula C8H12ClNO2 Melting Point 248-250 °C(lit.)
MSDS Chinese USA Flash Point 51.8 °F
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of Dopamine hydrochloride


Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.Target: Dopamine ReceptorDopamine (or 3,4-dihydroxyphenethylamine) is a neuroendocrine transmitter in the catecholamine and phenethylamine families that plays a number of important roles in the brain and bodies of humans. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system. Outside the nervous system, dopamine functions in several parts of the body as a local chemical messenger. In the blood vessels, it inhibits norepinephrine release and acts as a vasodilator; in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. A variety of important drugs work by altering the way the body makes or uses dopamine. Dopamine itself is available for intravenous injection: although it cannot reach the brain from the bloodstream, its peripheral effects make it useful in the treatment of heart failure or shock, especially in newborn babies. L-DOPA, the metabolic precursor of dopamine, does reach the brain and is the most widely used treatment for Parkinson's disease. From Wikipedia.

 Names

Name 3-Hydroxytyramine hydrochloride
Synonym More Synonyms

 Dopamine hydrochloride Biological Activity

Description Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.Target: Dopamine ReceptorDopamine (or 3,4-dihydroxyphenethylamine) is a neuroendocrine transmitter in the catecholamine and phenethylamine families that plays a number of important roles in the brain and bodies of humans. Several important diseases of the nervous system are associated with dysfunctions of the dopamine system. Outside the nervous system, dopamine functions in several parts of the body as a local chemical messenger. In the blood vessels, it inhibits norepinephrine release and acts as a vasodilator; in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. A variety of important drugs work by altering the way the body makes or uses dopamine. Dopamine itself is available for intravenous injection: although it cannot reach the brain from the bloodstream, its peripheral effects make it useful in the treatment of heart failure or shock, especially in newborn babies. L-DOPA, the metabolic precursor of dopamine, does reach the brain and is the most widely used treatment for Parkinson's disease. From Wikipedia.
Related Catalog
Target

Human Endogenous Metabolite
References

[1]. http://en.wikipedia.org/wiki/Dopamine

 Chemical & Physical Properties

Boiling Point 337.7ºC at 760 mmHg
Melting Point 248-250 °C(lit.)
Molecular Formula C8H12ClNO2
Molecular Weight 189.639
Exact Mass 189.055649
PSA 66.48000
LogP 2.10130
Stability Stable. Incompatible with strong oxidizing agents. Combustible.
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX1092000
CHEMICAL NAME :
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
CAS REGISTRY NUMBER :
62-31-7
LAST UPDATED :
199701
DATA ITEMS CITED :
22
MOLECULAR FORMULA :
C8-H11-N-O2.Cl-H
MOLECULAR WEIGHT :
189.66
WISWESSER LINE NOTATION :
Z2R CQ DQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2859 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
597 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
647 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4800 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4361 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
914 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1366 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
156 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
79 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
90 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
420 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
42 mg/kg/6W-I
TOXIC EFFECTS :
Cardiac - pulse rate increase, without fall in BP Cardiac - pulse rate
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
7 mg/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2100 ug/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
300 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
900 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
361 mg/kg
SEX/DURATION :
female 15 week(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
DOSE/DURATION :
93800 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 124,9,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3889 No. of Facilities: 135 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 5239 (estimated) No. of Female Employees: 3875 (estimated)

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS UX1092000
HS Code 29222900
Flash Point(F) 51.8 °F
Flash Point(C) 11 °C

 Synthetic Route

TRANS-3 4-BENZYLOXY-TRANS-B-NITROSTYREN& structure

TRANS-3 4-BENZY...

CAS#:1699-54-3

~96%

Dopamine hydrochloride Structure

Dopamine hydroc...

CAS#:62-31-7
Literature: Kohno; Sasao; Murahashi Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1252 - 1254
3,4-Dimethoxyphenethylamine structure

3,4-Dimethoxyph...

CAS#:120-20-7

~76%

Dopamine hydrochloride Structure

Dopamine hydroc...

CAS#:62-31-7
Literature: Velcicky, Juraj; Soicke, Arne; Steiner, Roland; Schmalz, Hans-Guenther Journal of the American Chemical Society, 2011 , vol. 133, # 18 p. 6948 - 6951
tert-butyl N-[2-(3,4-dihydroxyphenyl)ethyl]carbamate structure

tert-butyl N-[2...

CAS#:37034-31-4

~99%

Dopamine hydrochloride Structure

Dopamine hydroc...

CAS#:62-31-7
Literature: Bernini, Roberta; Crisante, Fernanda; Barontini, Maurizio; Fabrizi, Giancarlo Synthesis, 2009 , # 22 art. no. P09409SS, p. 3838 - 3842
3,4-Dimethoxyphenylacetonitrile structure

3,4-Dimethoxyph...

CAS#:93-17-4

~%

Dopamine hydrochloride Structure

Dopamine hydroc...

CAS#:62-31-7
Literature: Journal of the American Chemical Society, , vol. 133, # 18 p. 6948 - 6951

 Customs

HS Code 29222900

 Articles206

More Articles
'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile.

FEBS J. 282(6) , 1137-51, (2015)

Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet-Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety...
Permeation of Dopamine Sulfate through the Blood-Brain Barrier.

PLoS ONE 10 , e0133904, (2015)

Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from per...
Increasing the Collision Rate of Particle Impact Electroanalysis with Magnetically Guided Pt-Decorated Iron Oxide Nanoparticles.

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An integrated microfluidic/magnetophoretic methodology was developed for improving signal response time and detection limits for the chronoamperometric observation of discrete nanoparticle/electrode i...

 Synonyms

3,4-Dihydroxy-b-phenethylamine Hydrochloride
4-(2-aminoéthyl)benzène-1,2-diol chlorhydrate
b-(3,4-Dihydroxyphenyl)ethylamine Hydrochloride
Tensamin
4-(2-Aminoethyl)benzene-1,2-diol hydrochloride (1:1)
Rascordin
Pyrocatechol, 4- (2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1)
4-(2-aminoethyl)benzene-1,2-diol,hydrochloride
1,2-Benzenediol, 4- (2-aminoethyl)-, hydrochloride
4-(2-Aminoethyl)-1,2-benzenediol hydrochloride (1:1)
4-(2-aminoethyl)-Pyrocatechol hydrochloride
4-(2-Aminoethyl)benzol-1,2-diolhydrochlorid
EINECS 200-527-8
MFCD00012898
4-(2-Aminoethyl)catechol, hydrochloride
β-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
Dopamine (hydrochloride)
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Related Compounds: More...
Dopamine hydrochloride
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N-(Methyl-d3)dopamine Hydrochloride
101905-96-8
Dopamine-d5 hydrochloride
2193106-55-5
Dopamine-d4 Hydrochloride
203633-19-6
dopamine
51-61-6
dopamine D4 receptor
137750-34-6
dopamine D5 receptor
137750-35-7
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