n-methyldopamine hydrochloride

Modify Date: 2024-01-02 17:39:22

n-methyldopamine hydrochloride structure	Common Name	n-methyldopamine hydrochloride
	CAS Number	62-32-8	Molecular Weight	203.666
	Density	N/A	Boiling Point	328.6ºC at 760 mmHg
	Molecular Formula	C₉H₁₄ClNO₂	Melting Point	174-176ºC
	MSDS	N/A	Flash Point	154.3ºC

Use of n-methyldopamine hydrochloride

N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research[1][2][3].

Name	4-[2-(methylamino)ethyl]benzene-1,2-diol,hydrochloride
Synonym	More Synonyms

Description	N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D1 Receptor
In Vitro	N-Methyldopamine hydrochloride shows highly improved surface coating properties, and exhibits an accelerated coating rate. N-Methyldopamine hydrochloride coating makes solid surface cell adhesion possible, and postfunctionalization of the coating is also possible[1].
References	[1]. Kim Y, et al. Effect of N-Methylation on Dopamine Surface Chemistry. Langmuir. 2022 May 24;38(20):6404-6410. [2]. Laduron P. N-Methyldopamine (epinine), a precursor of adrenaline in the adrenal medulla. Arch Int Pharmacodyn Ther. 1972 Apr;196:Suppl 196:304-. [3]. Rajfer SI, et al. Effects of long-term therapy with oral ibopamine on resting hemodynamics and exercise capacity in patients with heart failure: relationship to the generation of N-methyldopamine and to plasma norepinephrine levels. Circulation. 1986 Apr;73(4):740-8.

Boiling Point	328.6ºC at 760 mmHg
Melting Point	174-176ºC
Molecular Formula	C₉H₁₄ClNO₂
Molecular Weight	203.666
Flash Point	154.3ºC
Exact Mass	203.071304
PSA	52.49000
LogP	2.05260
Appearance of Characters	solid \| white
Storage condition	2-8°C
Water Solubility	H2O: soluble

n-methyldopamine hydrochloride MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1925000

CHEMICAL NAME :: Pyrocatechol, 4-(2-(methylamino)ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 62-32-8

LAST UPDATED :: 199012

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H13-N-O2.Cl-H

MOLECULAR WEIGHT :: 203.69

WISWESSER LINE NOTATION :: QR BQ D2M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,1194,1975 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

Hazard Codes	Xi
WGK Germany	3
RTECS	UX1925000
HS Code	2922299090

Adrenalone hydr...

CAS#:62-13-5

~88%

n-methyldopamin...

CAS#:62-32-8

Literature: Carpenter, Joel F. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1607 - 1609

DL-Adrenalin

CAS#:329-65-7

n-methyldopamin...

CAS#:62-32-8

Literature: Carpenter, Joel F. Journal of Organic Chemistry, 1993 , vol. 58, # 6 p. 1607 - 1609

Precursor 2
CAS#:62-13-5 Adrenalone hydr... CAS#:329-65-7 DL-Adrenalin
DownStream 2
CAS#:3736-29-6 2,3-Dihydro-1-m... CAS#:66195-31-1 [4-[2-(methylam...

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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