Diphenmanil (methylsulfate)
Modify Date: 2026-07-04 20:13:11
Diphenmanil (methylsulfate) structure
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Common Name | Diphenmanil (methylsulfate) | ||
|---|---|---|---|---|
| CAS Number | 62-97-5 | Molecular Weight | 389.50800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H27NO4S | Melting Point | 194-195ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of Diphenmanil (methylsulfate)Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.IC50 value: Target: mAChRDiphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | diphemanil methylsulfate |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Diphemanil methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.IC50 value: Target: mAChRDiphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 194-195ºC |
|---|---|
| Molecular Formula | C21H27NO4S |
| Molecular Weight | 389.50800 |
| Exact Mass | 389.16600 |
| PSA | 74.81000 |
| LogP | 4.49130 |
| InChIKey | BREMLQBSKCSNNH-UHFFFAOYSA-M |
| SMILES | COS(=O)(=O)[O-].C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600
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Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958
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Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Talpran |
| Diphenmethanil |
| Nivelona |
| Demotil |
| DIPHEMANIL METHYLSULFATE |
| Diphemanil Methylsulfate |
| Variton |
| Diphemanil metilsulfate |
| Diphenmanil (methylsulfate) |
| Diphemanil |
| 4-benzhydrylidene-1,1-dimethyl-piperidinium,methyl sulfate |
| 4-Benzhydryliden-1,1-dimethyl-piperidinium,Methylsulfat |
| 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium,methyl sulfate |
| Prantal |
| Nivelon |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of diphemanil methylsulfate? |
| A: Melting point of diphemanil methylsulfate is 194-195ºC. |
| Q: What English synonyms does diphemanil methylsulfate have? |
| A: English synonyms of diphemanil methylsulfate: Talpran, Diphenmethanil, Nivelona, Demotil, DIPHEMANIL METHYLSULFATE, Diphemanil Methylsulfate, Variton, Diphemanil metilsulfate, Diphenmanil (methylsulfate), Diphemanil, 4-benzhydrylidene-1,1-dimethyl-piperidinium,methyl sulfate, 4-Benzhydryliden-1,1-dimethyl-piperidinium,Methylsulfat, 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium,methyl sulfate, Prantal, Nivelon. |
| Q: What is the CAS number of diphemanil methylsulfate? |
| A: CAS number of diphemanil methylsulfate is 62-97-5. |
| Q: What is the molecular weight of diphemanil methylsulfate? |
| A: Molecular weight of diphemanil methylsulfate is 389.50800. |
| Q: What is the molecular formula of diphemanil methylsulfate? |
| A: Molecular formula of diphemanil methylsulfate is C21H27NO4S. |
| Q: What is the LogP of diphemanil methylsulfate? |
| A: LogP of diphemanil methylsulfate is 4.49130. |
| Q: What is the polar surface area (PSA) of diphemanil methylsulfate? |
| A: Polar surface area (PSA) of diphemanil methylsulfate is 74.81000. |
| Q: What is the English name of diphemanil methylsulfate? |
| A: The English name of diphemanil methylsulfate is diphemanil methylsulfate. |
| Q: What is the InChIKey of diphemanil methylsulfate? |
| A: InChIKey of diphemanil methylsulfate is BREMLQBSKCSNNH-UHFFFAOYSA-M. |
| Q: What is the SMILES notation of diphemanil methylsulfate? |
| A: SMILES notation of diphemanil methylsulfate is COS(=O)(=O)[O-].C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |