甲硫二苯马尼

• 常用名: 甲硫二苯马尼
• 英文名: Diphenmanil (methylsulfate)
• CAS号: 62-97-5
• 分子量: 389.50800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₇NO₄S
• 熔点: 194-195ºC
• 闪点: N/A

甲硫二苯马尼用途

Diphemanil硫酸二甲酯能结合毒蕈碱型乙酰胆碱受体进而降低胃酸,唾液和汗液的分泌排泄。

甲硫二苯马尼名称

• 中文名: 甲硫二苯马尼
• 英文名: diphemanil methylsulfate
• 中文别名: N,N-二甲基-4-哌啶亚基-1,1-二苯甲烷甲基硫酸盐 | 吡拉西坦

甲硫二苯马尼生物活性

• 描述: Diphemanil硫酸二甲酯能结合毒蕈碱型乙酰胆碱受体进而降低胃酸,唾液和汗液的分泌排泄。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 内分泌
• 参考文献:

  [1]. Küng M, Diamond L. Effect of inhaled diphemanil methylsulfate, a parasympatholytic agent, on histamine induced bronchoconstriction in asymptomatic asthmatics. Ann Allergy. 1984 Jan;52(1):22-5.

  [2]. Vidal AM, Rey E, Pons G et al. Pharmacokinetics of diphemanil methylsulphate in healthy subjects. Eur J Clin Pharmacol. 1992;42(6):689-91.

  [3]. Vidal AM, Chéron G, Rey E et al. Pharmacokinetics of diphemanil methylsulphate in infants. Eur J Clin Pharmacol. 1993;45(1):89-91.

  [4]. Chéron G, Vidal AM, Rey E et al. [Pharmacokinetics of diphemanil methylsulfate in infants]. Arch Pediatr. 1994 Jan;1(1):33-7.

  [5]. Adamantidis M, Dumotier B, Caron J, Dupuis B. [Electrophysiologic effects and arrhythmogenic potential of diphemanil methylsulfate on rabbit purkinje fibers. Correlations with clinical observations of QT prolongation in pediatrics]. Arch Mal Coeur Vaiss.

甲硫二苯马尼物理化学性质

• 熔点: 194-195ºC
• 分子式: C₂₁H₂₇NO₄S
• 分子量: 389.50800
• 精确质量: 389.16600
• PSA: 74.81000
• LogP: 4.49130
• InChIKey: BREMLQBSKCSNNH-UHFFFAOYSA-M
• SMILES: COS(=O)(=O)[O-].C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1
• 储存条件: 室温，干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:2

  5.互变异构体数量:无

  6.拓扑分子极性表面积:74.8

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:426

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

甲硫二苯马尼毒性和生态

甲硫二苯马尼靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce... 来源：824 靶标：N/A External Id：P53MS958

实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary 来源：824 External Id：P53MS482

共376条，当前第1页，共38页

1

2

3

4

5

甲硫二苯马尼英文别名

• Talpran
• Diphenmethanil
• Nivelona
• Demotil
• DIPHEMANIL METHYLSULFATE
• Diphemanil Methylsulfate
• Variton
• Diphemanil metilsulfate
• Diphenmanil (methylsulfate)
• Diphemanil
• 4-benzhydrylidene-1,1-dimethyl-piperidinium,methyl sulfate
• 4-Benzhydryliden-1,1-dimethyl-piperidinium,Methylsulfat
• 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium,methyl sulfate
• Prantal
• Nivelon