12-O-Methylcarnosic acid
Modify Date: 2024-01-12 10:42:09
12-O-Methylcarnosic acid structure
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Common Name | 12-O-Methylcarnosic acid | ||
|---|---|---|---|---|
| CAS Number | 62201-71-2 | Molecular Weight | 346.461 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 505.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H30O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 173.3±23.6 °C | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of 12-O-Methylcarnosic acid12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2]. |
| Name | (4aR,10aS)-5-hydroxy-7-isopropyl-6-methoxy-1,1-dimethyl-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid |
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| Synonym | More Synonyms |
| Description | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2]. |
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| Related Catalog | |
| In Vitro | 12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1]. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL[2]. |
| References |
[2]. Zeynep Aydogmuş, et al. Constituents of Salvia Microphylla. Nat Prod Res. 2006 Jul 10;20(8):775-81. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 505.1±50.0 °C at 760 mmHg |
| Molecular Formula | C21H30O4 |
| Molecular Weight | 346.461 |
| Flash Point | 173.3±23.6 °C |
| Exact Mass | 346.214417 |
| PSA | 66.76000 |
| LogP | 5.23 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.551 |
| Storage condition | ?20°C |
| 11-Hydroxy-12-methoxyabieta-8(14),9(11),12-trien-20-oic acid |
| 4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5-hydroxy-6-methoxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)- |