12-O-Methylcarnosic acid

Modify Date: 2025-08-27 15:09:01

12-O-Methylcarnosic acid Structure
12-O-Methylcarnosic acid structure
Common Name 12-O-Methylcarnosic acid
CAS Number 62201-71-2 Molecular Weight 346.461
Density 1.1±0.1 g/cm3 Boiling Point 505.1±50.0 °C at 760 mmHg
Molecular Formula C21H30O4 Melting Point N/A
MSDS Chinese USA Flash Point 173.3±23.6 °C
Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning

 Use of 12-O-Methylcarnosic acid


12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2].

 Names

Name (4aR,10aS)-5-hydroxy-7-isopropyl-6-methoxy-1,1-dimethyl-1,3,4,9,10,10a-hexahydrophenanthrene-4a(2H)-carboxylic acid
Synonym More Synonyms

 12-O-Methylcarnosic acid Biological Activity

Description 12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2].
Related Catalog
In Vitro 12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1]. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL[2].
References

[1]. Kazuya Murata, et al. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract. Phytother Res. 2013 Feb;27(2):212-7.

[2]. Zeynep Aydogmuş, et al. Constituents of Salvia Microphylla. Nat Prod Res. 2006 Jul 10;20(8):775-81.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 505.1±50.0 °C at 760 mmHg
Molecular Formula C21H30O4
Molecular Weight 346.461
Flash Point 173.3±23.6 °C
Exact Mass 346.214417
PSA 66.76000
LogP 5.23
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.551
Storage condition ?20°C

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H410
Precautionary Statements P273-P501
Hazard Codes Xn,N
Risk Phrases 22-50
Safety Phrases 61
RIDADR UN 3077 9 / PGIII

 Synonyms

11-Hydroxy-12-methoxyabieta-8(14),9(11),12-trien-20-oic acid
4a(2H)-Phenanthrenecarboxylic acid, 1,3,4,9,10,10a-hexahydro-5-hydroxy-6-methoxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,10aS)-
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