XL-844
Modify Date: 2025-09-22 11:42:20
XL-844 structure
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Common Name | XL-844 | ||
|---|---|---|---|---|
| CAS Number | 631864-00-1 | Molecular Weight | 287.323 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H17N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of XL-844A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model. Blood Cancer Phase 1 Discontinued |
| Name | XL-844 |
|---|
| Description | A potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively; increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry; significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model. Blood Cancer Phase 1 Discontinued |
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| References | References 1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22. 2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10. View Related Products by Target Checkpoint Kinase (Chk) Blood Cancer |
| Molecular Formula | C14H17N5O2 |
|---|---|
| Molecular Weight | 287.323 |
| InChIKey | UVSSZSQSZGKMAL-UHFFFAOYSA-N |
| SMILES | NCCCOc1ccccc1NC(=O)Nc1cnccn1 |